ID:LRRC7_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 7; AltName: Full=Densin-180; Short=Densin; AltName: Full=Protein LAP1; FUNCTION: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression. SUBUNIT: Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N- cadherin through CTNND2. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). TISSUE SPECIFICITY: Brain-specific. Isoform 3 is ubiquitously expressed. SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family. SIMILARITY: Contains 17 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 PDZ (DHR) domain. SEQUENCE CAUTION: Sequence=AAP06801.1; Type=Erroneous initiation; Sequence=BAA92603.1; Type=Frameshift; Positions=665; Sequence=CAH70975.1; Type=Erroneous initiation; Sequence=CAH73692.1; Type=Erroneous initiation; Sequence=CAH74019.1; Type=Erroneous initiation; Sequence=CAI22426.1; Type=Erroneous initiation; Sequence=CAI23423.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Attention Deficit Disorder with Hyperactivity Eric Mick et al. Journal of the American Academy of Child and Adolescent Psychiatry 2011, Genome-wide association study of the child behavior checklist dysregulation profile., Journal of the American Academy of Child and Adolescent Psychiatry.
We found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
Body Height Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
Hypertension Se Joong Kim et al. Circulation journal 2012, Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study., Circulation journal : official journal of the Japanese Circulation Society.
This prospective communitywide study showed that premenopausal women with short sleep duration had an increased risk of incident HT, and found associations with specific genomic markers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96NW7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.