Human Gene GTSE1 (uc011aqy.2) Description and Page Index
  Description: Homo sapiens G-2 and S-phase expressed 1 (GTSE1), mRNA.
RefSeq Summary (NM_016426): The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075828.1, AK025563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000454366.2/ ENSP00000415430.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr22:46,692,638-46,726,707 Size: 34,070 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr22:46,693,298-46,726,027 Size: 32,730 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:46,692,638-46,726,707)mRNA (may differ from genome)Protein (739 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GTSE1_HUMAN
DESCRIPTION: RecName: Full=G2 and S phase-expressed protein 1; Short=GTSE-1; AltName: Full=Protein B99 homolog;
FUNCTION: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Associated with microtubules.
DEVELOPMENTAL STAGE: Expressed in G2/M phase. Not detected in quiescent cells.
PTM: Phosphorylated in mitosis (By similarity).
SEQUENCE CAUTION: Sequence=CAQ09324.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ10552.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GTSE1
CDC HuGE Published Literature: GTSE1

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 42.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.24212-0.374 Picture PostScript Text
3' UTR -215.30680-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026657 - DDA3/GTSE-1
IPR026659 - GTSE1

Pfam Domains:
PF15259 - G-2 and S-phase expressed 1

ModBase Predicted Comparative 3D Structure on Q9NYZ3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007017 microtubule-based process
GO:0030335 positive regulation of cell migration
GO:0046827 positive regulation of protein export from nucleus
GO:0050821 protein stabilization
GO:1900182 positive regulation of protein localization to nucleus
GO:1902749 regulation of cell cycle G2/M phase transition

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC075828 - Homo sapiens G-2 and S-phase expressed 1, mRNA (cDNA clone MGC:88566 IMAGE:5092448), complete cds.
AK303087 - Homo sapiens cDNA FLJ54919 complete cds, highly similar to G2 and S phase expressed protein 1.
AK315550 - Homo sapiens cDNA, FLJ96619, Homo sapiens G-2 and S-phase expressed 1 (GTSE1), mRNA.
AK222806 - Homo sapiens mRNA for G-2 and S-phase expressed 1 variant, clone: HEP03852.
AK025563 - Homo sapiens cDNA: FLJ21910 fis, clone HEP03852, highly similar to AF223408 Homo sapiens B99 mRNA.
AF223408 - Homo sapiens B99 mRNA, complete cds.
BC006325 - Homo sapiens G-2 and S-phase expressed 1, mRNA (cDNA clone MGC:12560 IMAGE:4138532), complete cds.
CT841519 - Homo sapiens GTSE1 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.GTSE1).
CU675353 - Synthetic construct Homo sapiens gateway clone IMAGE:100023485 5' read GTSE1 mRNA.
AB463048 - Synthetic construct DNA, clone: pF1KB8720, Homo sapiens GTSE1 gene for G-2 and S-phase expressed protein 1, without stop codon, in Flexi system.
CU013387 - Homo sapiens GTSE1, mRNA (cDNA clone IMAGE:100000262), complete cds, without stop codon, in Gateway system.
DQ896020 - Synthetic construct Homo sapiens clone IMAGE:100010480; FLH189562.01L; RZPDo839G0764D G-2 and S-phase expressed 1 (GTSE1) gene, encodes complete protein.
DQ892771 - Synthetic construct clone IMAGE:100005401; FLH189566.01X; RZPDo839G0774D G-2 and S-phase expressed 1 (GTSE1) gene, encodes complete protein.
CU013099 - Homo sapiens GTSE1, mRNA (cDNA clone IMAGE:100000358), complete cds, with stop codon, in Gateway system.
KJ902601 - Synthetic construct Homo sapiens clone ccsbBroadEn_11995 GTSE1 gene, encodes complete protein.
KJ902600 - Synthetic construct Homo sapiens clone ccsbBroadEn_11994 GTSE1 gene, encodes complete protein.
CU687298 - Synthetic construct Homo sapiens gateway clone IMAGE:100023171 5' read GTSE1 mRNA.
AY927426 - Homo sapiens mRNA sequence.
AY927427 - Homo sapiens mRNA sequence.
AY927424 - Homo sapiens mRNA sequence.
AY927428 - Homo sapiens mRNA sequence.
AY927425 - Homo sapiens mRNA sequence.
JD498020 - Sequence 479044 from Patent EP1572962.
JD285331 - Sequence 266355 from Patent EP1572962.
JD490854 - Sequence 471878 from Patent EP1572962.
JD266550 - Sequence 247574 from Patent EP1572962.
JD144426 - Sequence 125450 from Patent EP1572962.
JD462388 - Sequence 443412 from Patent EP1572962.
JD431015 - Sequence 412039 from Patent EP1572962.
JD558823 - Sequence 539847 from Patent EP1572962.
JD443014 - Sequence 424038 from Patent EP1572962.
JD340924 - Sequence 321948 from Patent EP1572962.
JD500591 - Sequence 481615 from Patent EP1572962.
JD289300 - Sequence 270324 from Patent EP1572962.
JD289301 - Sequence 270325 from Patent EP1572962.
JD256946 - Sequence 237970 from Patent EP1572962.
JD319565 - Sequence 300589 from Patent EP1572962.
JD220771 - Sequence 201795 from Patent EP1572962.
JD530643 - Sequence 511667 from Patent EP1572962.
JD171019 - Sequence 152043 from Patent EP1572962.
JD134187 - Sequence 115211 from Patent EP1572962.
JD532591 - Sequence 513615 from Patent EP1572962.
JD230030 - Sequence 211054 from Patent EP1572962.
JD269592 - Sequence 250616 from Patent EP1572962.
JD366443 - Sequence 347467 from Patent EP1572962.
JD517592 - Sequence 498616 from Patent EP1572962.
JD399281 - Sequence 380305 from Patent EP1572962.
JD523645 - Sequence 504669 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04115 - p53 signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q9NYZ3 (Reactome details) participates in the following event(s):

R-HSA-8852280 GTSE1 binds microtubule lattice in interphase cells
R-HSA-8852298 GTSE1 binds MAPRE1 (EB1) at microtubule plus ends
R-HSA-8852324 GTSE1 binds PLK1
R-HSA-8852362 GTSE1 binds CDKN1A
R-HSA-8852306 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends
R-HSA-8852331 GTSE1 translocates to the nucleus
R-HSA-8852317 PLK1 phosphorylates GTSE1
R-HSA-8852337 GTSE1 binds TP53
R-HSA-8852351 GTSE1 promotes translocation of TP53 to the cytosol
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69275 G2/M Transition
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-1640170 Cell Cycle
R-HSA-69278 Cell Cycle (Mitotic)

-  Other Names for This Gene
  Alternate Gene Symbols: B0QYM3, GTSE1_HUMAN, NM_016426, NP_057510, Q20WK2, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9NYZ3, Q9UGZ9, Q9Y557
UCSC ID: uc011aqy.2
RefSeq Accession: NM_016426
Protein: Q9NYZ3 (aka GTSE1_HUMAN or GTSE_HUMAN)
CCDS: CCDS14074.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_016426.6
exon count: 12CDS single in 3' UTR: no RNA size: 3128
ORF size: 2220CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4623.50frame shift in genome: no % Coverage: 99.49
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.