Human Gene GTSE1 (uc011aqy.2) Description and Page Index
Description: Homo sapiens G-2 and S-phase expressed 1 (GTSE1), mRNA. RefSeq Summary (NM_016426): The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC075828.1, AK025563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000454366.2/ ENSP00000415430.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr22:46,692,638-46,726,707 Size: 34,070 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr22:46,693,298-46,726,027 Size: 32,730 Coding Exon Count: 11
ID:GTSE1_HUMAN DESCRIPTION: RecName: Full=G2 and S phase-expressed protein 1; Short=GTSE-1; AltName: Full=Protein B99 homolog; FUNCTION: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Associated with microtubules. DEVELOPMENTAL STAGE: Expressed in G2/M phase. Not detected in quiescent cells. PTM: Phosphorylated in mitosis (By similarity). SEQUENCE CAUTION: Sequence=CAQ09324.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ10552.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GTSE1 CDC HuGE Published Literature: GTSE1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF15259 - G-2 and S-phase expressed 1
ModBase Predicted Comparative 3D Structure on Q9NYZ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007017 microtubule-based process GO:0030335 positive regulation of cell migration GO:0046827 positive regulation of protein export from nucleus GO:0050821 protein stabilization GO:1900182 positive regulation of protein localization to nucleus GO:1902749 regulation of cell cycle G2/M phase transition