Human Gene KIF4A (uc004dyg.3) Description and Page Index
Description: Homo sapiens kinesin family member 4A (KIF4A), mRNA. RefSeq Summary (NM_012310): This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF071592.2, AB208797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374403.4/ ENSP00000363524.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:69,509,879-69,640,774 Size: 130,896 Total Exon Count: 31 Strand: + Coding Region Position: hg19 chrX:69,510,309-69,640,115 Size: 129,807 Coding Exon Count: 30
ID:KIF4A_HUMAN DESCRIPTION: RecName: Full=Chromosome-associated kinesin KIF4A; AltName: Full=Chromokinesin-A; FUNCTION: Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. SUBUNIT: Interacts with unphosphorylated PRC1 during late mitosis. SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis. TISSUE SPECIFICITY: Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. SIMILARITY: Belongs to the kinesin-like protein family. Chromokinesin subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAH49218.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95239
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000281 mitotic cytokinesis GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006996 organelle organization GO:0007018 microtubule-based movement GO:0008089 anterograde axonal transport GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0051256 mitotic spindle midzone assembly
AK313133 - Homo sapiens cDNA, FLJ93621, highly similar to Homo sapiens kinesin family member 4A (KIF4A), mRNA. BC003664 - Homo sapiens kinesin family member 4A, mRNA (cDNA clone IMAGE:3010167), partial cds. BC038459 - Homo sapiens, Similar to kinesin family member 4A, clone IMAGE:5534401, mRNA. AF071592 - Homo sapiens kinesin superfamily motor KIF4 mRNA, complete cds. AB208797 - Homo sapiens mRNA for Chromosome-associated kinesin KIF4A variant protein. BC050548 - Homo sapiens kinesin family member 4A, mRNA (cDNA clone MGC:57639 IMAGE:4538604), complete cds. AB384408 - Synthetic construct DNA, clone: pF1KSDB3041, Homo sapiens KIF4A gene for kinesin family member 4A, complete cds, without stop codon, in Flexi system. AJ271784 - Homo sapiens mRNA for Chromokinesin (KIF 4 gene). AF179308 - Homo sapiens KIF4 (KIF4) mRNA, complete cds. AF277375 - Homo sapiens chromokinesin mRNA, partial cds. AK022592 - Homo sapiens cDNA FLJ12530 fis, clone NT2RM4000167, highly similar to Homo sapiens mRNA for Chromokinesin (KIF 4 gene). AK022717 - Homo sapiens cDNA FLJ12655 fis, clone NT2RM4002109, highly similar to Homo sapiens mRNA for Chromokinesin (KIF 4 gene). AK024266 - Homo sapiens cDNA FLJ14204 fis, clone NT2RP3003138, highly similar to Chromosome-associated kinesin KIF4A. JD471915 - Sequence 452939 from Patent EP1572962. BC049218 - Homo sapiens kinesin family member 4A, mRNA (cDNA clone IMAGE:5497667), partial cds. BC011801 - Homo sapiens kinesin family member 4A, mRNA (cDNA clone IMAGE:4423083), with apparent retained intron. LF381705 - JP 2014500723-A/189208: Polycomb-Associated Non-Coding RNAs. MA617282 - JP 2018138019-A/189208: Polycomb-Associated Non-Coding RNAs. AK000638 - Homo sapiens cDNA FLJ20631 fis, clone KAT03761, highly similar to AF071592 Homo sapiens kinesin superfamily motor KIF4 mRNA. JD541147 - Sequence 522171 from Patent EP1572962. JD494071 - Sequence 475095 from Patent EP1572962. JD215753 - Sequence 196777 from Patent EP1572962. JD323715 - Sequence 304739 from Patent EP1572962. JD183124 - Sequence 164148 from Patent EP1572962. JD324608 - Sequence 305632 from Patent EP1572962. JD486941 - Sequence 467965 from Patent EP1572962. JD179877 - Sequence 160901 from Patent EP1572962. JD507759 - Sequence 488783 from Patent EP1572962. JD229047 - Sequence 210071 from Patent EP1572962. JD256140 - Sequence 237164 from Patent EP1572962.