Human Gene ARHGAP11A (uc001zgy.1) Description and Page Index
  Description: Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA.
RefSeq Summary (NM_014783): This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019].
Transcript (Including UTRs)
   Position: hg19 chr15:32,907,691-32,931,868 Size: 24,178 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr15:32,908,413-32,930,046 Size: 21,634 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:32,907,691-32,931,868)mRNA (may differ from genome)Protein (1023 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Rho GTPase-activating protein 11A; AltName: Full=Rho-type GTPase-activating protein 11A;
SIMILARITY: Contains 1 Rho-GAP domain.
SEQUENCE CAUTION: Sequence=BAA13442.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.94 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 48.81 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -271.49722-0.376 Picture PostScript Text
3' UTR -450.131822-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom

Pfam Domains:
PF00620 - RhoGAP domain

SCOP Domains:
48350 - GTPase activation domain, GAP

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q6P4F7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction

Cellular Component:
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AK316437 - Homo sapiens cDNA, FLJ79336 complete cds, highly similar to Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA.
D87717 - Homo sapiens KIAA0013 mRNA.
BC050545 - Homo sapiens Rho GTPase activating protein 11A, mRNA (cDNA clone IMAGE:5551861).
BC063444 - Homo sapiens Rho GTPase activating protein 11A, mRNA (cDNA clone IMAGE:5502381), complete cds.
AK303025 - Homo sapiens cDNA FLJ50314 complete cds, highly similar to Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA.
JD107235 - Sequence 88259 from Patent EP1572962.
JD395494 - Sequence 376518 from Patent EP1572962.
BC039563 - Homo sapiens Rho GTPase activating protein 11A, mRNA (cDNA clone MGC:8750 IMAGE:3913511), complete cds.
JD443711 - Sequence 424735 from Patent EP1572962.
JD329777 - Sequence 310801 from Patent EP1572962.
JD483779 - Sequence 464803 from Patent EP1572962.
JD214964 - Sequence 195988 from Patent EP1572962.
JD346932 - Sequence 327956 from Patent EP1572962.
JD056816 - Sequence 37840 from Patent EP1572962.
CU687726 - Synthetic construct Homo sapiens gateway clone IMAGE:100022872 5' read ARHGAP11A mRNA.
HQ447498 - Synthetic construct Homo sapiens clone IMAGE:100070834; CCSB014224_02 Rho GTPase activating protein 11A (ARHGAP11A) gene, encodes complete protein.
KJ892858 - Synthetic construct Homo sapiens clone ccsbBroadEn_02252 ARHGAP11A gene, encodes complete protein.
GQ129289 - Synthetic construct Homo sapiens clone HAIB:100068560; DKFZo008B0535 Rho GTPase activating protein 11A protein (ARHGAP11A) gene, complete cds.
GQ129290 - Synthetic construct Homo sapiens clone HAIB:100068656; DKFZo004B0536 Rho GTPase activating protein 11A protein (ARHGAP11A) gene, partial cds.
AB463224 - Synthetic construct DNA, clone: pF1KA0013, Homo sapiens ARHGAP11A gene for Rho GTPase activating protein 11A, without stop codon, in Flexi system.
DQ588822 - Homo sapiens piRNA piR-55934, complete sequence.
JD507867 - Sequence 488891 from Patent EP1572962.
JD240271 - Sequence 221295 from Patent EP1572962.
JD174345 - Sequence 155369 from Patent EP1572962.
JD325957 - Sequence 306981 from Patent EP1572962.
JD461041 - Sequence 442065 from Patent EP1572962.
JD139686 - Sequence 120710 from Patent EP1572962.
JD450510 - Sequence 431534 from Patent EP1572962.
JD048100 - Sequence 29124 from Patent EP1572962.
JD352392 - Sequence 333416 from Patent EP1572962.
JD524538 - Sequence 505562 from Patent EP1572962.
JD059630 - Sequence 40654 from Patent EP1572962.
JD256012 - Sequence 237036 from Patent EP1572962.
JD256013 - Sequence 237037 from Patent EP1572962.
JD426797 - Sequence 407821 from Patent EP1572962.
JD450445 - Sequence 431469 from Patent EP1572962.
JD561503 - Sequence 542527 from Patent EP1572962.
JD314135 - Sequence 295159 from Patent EP1572962.
JD265095 - Sequence 246119 from Patent EP1572962.
JD177739 - Sequence 158763 from Patent EP1572962.
JD313165 - Sequence 294189 from Patent EP1572962.
JD288465 - Sequence 269489 from Patent EP1572962.
JD346019 - Sequence 327043 from Patent EP1572962.
JD244602 - Sequence 225626 from Patent EP1572962.
JD062846 - Sequence 43870 from Patent EP1572962.
JD435681 - Sequence 416705 from Patent EP1572962.
MH721904 - Homo sapiens ARHGAP11A_7 (ARHGAP11A) mRNA, complete sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6P4F7 (Reactome details) participates in the following event(s):

R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis
R-HSA-194840 Rho GTPase cycle
R-HSA-194315 Signaling by Rho GTPases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0013, NM_014783, NP_055598, Q6P4F7, Q6PI96, Q9Y3S6, RHGBA_HUMAN
UCSC ID: uc001zgy.1
RefSeq Accession: NM_014783
Protein: Q6P4F7 (aka RHGBA_HUMAN)
CCDS: CCDS10028.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014783.3
exon count: 12CDS single in 3' UTR: no RNA size: 5616
ORF size: 3072CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6254.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.