Human Gene POLE2 (uc001wwu.3) Description and Page Index
Description: Homo sapiens polymerase (DNA directed), epsilon 2, accessory subunit (POLE2), transcript variant 1, mRNA. RefSeq Summary (NM_002692): DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]. Transcript (Including UTRs) Position: hg19 chr14:50,110,270-50,155,098 Size: 44,829 Total Exon Count: 19 Strand: - Coding Region Position: hg19 chr14:50,110,370-50,154,921 Size: 44,552 Coding Exon Count: 19
ID:DPOE2_HUMAN DESCRIPTION: RecName: Full=DNA polymerase epsilon subunit 2; EC=22.214.171.124; AltName: Full=DNA polymerase II subunit 2; AltName: Full=DNA polymerase epsilon subunit B; FUNCTION: Participates in DNA repair and in chromosomal DNA replication. CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SUBUNIT: Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis. SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pole2/";
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): POLE2 CDC HuGE Published Literature: POLE2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56282
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.