Human Gene SKA3 (uc001unt.3) Description and Page Index
Description: Homo sapiens spindle and kinetochore associated complex subunit 3 (SKA3), transcript variant 1, mRNA. RefSeq Summary (NM_145061): This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr13:21,727,734-21,750,741 Size: 23,008 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr13:21,729,289-21,750,616 Size: 21,328 Coding Exon Count: 9
ID:SKA3_HUMAN DESCRIPTION: RecName: Full=Spindle and kinetochore-associated protein 3; FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. SUBUNIT: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. SIMILARITY: Belongs to the SKA3 family. SEQUENCE CAUTION: Sequence=AAH13418.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=BAG37379.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG37379.1; Type=Frameshift; Positions=29; Sequence=CAH69950.1; Type=Erroneous gene model prediction; Sequence=EAX08294.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IX90
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.