ID:HELQ_HUMAN DESCRIPTION: RecName: Full=Helicase POLQ-like; EC=184.108.40.206; AltName: Full=Mus308-like helicase; AltName: Full=POLQ-like helicase; FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Hexamer. MISCELLANEOUS: ATPase activity is strongly stimulated by single- stranded DNA. Presence of ATP and Mg cofactor are required for helicase activity allowing to unwind duplex oligonucleotides up to 60-70-mer. This helicase activity is stimulated by replication protein RPA that binds to unwound regions and inhibits re- annealing. SIMILARITY: Belongs to the helicase family. SKI2 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.
Genetic Association Studies of Complex Diseases and Disorders
Head and Neck Neoplasms James D McKay et al. PLoS genetics 2011, A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium., PLoS genetics.
Menopause Lisette Stolk et al. Nature genetics 2012, Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways., Nature genetics.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDG4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.