Human Gene CBWD2 (uc002tju.3) Description and Page Index
  Description: Homo sapiens COBW domain containing 2 (CBWD2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:114,195,268-114,253,781 Size: 58,514 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr2:114,195,446-114,253,320 Size: 57,875 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:114,195,268-114,253,781)mRNA (may differ from genome)Protein (395 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CBWD2_HUMAN
DESCRIPTION: RecName: Full=COBW domain-containing protein 2; AltName: Full=Cobalamin synthase W domain-containing protein 2;
INTERACTION: P27348:YWHAQ; NbExp=1; IntAct=EBI-359159, EBI-359854;
SIMILARITY: Belongs to the CobW family.
SIMILARITY: Contains 1 cobW C-terminal domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.68 RPKM in Thyroid
Total median expression: 196.21 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.10178-0.461 Picture PostScript Text
3' UTR -89.82461-0.195 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011629 - Cbl_biosynth_CobW-like_C
IPR003495 - CobW/HypB/UreG_dom

Pfam Domains:
PF02492 - CobW/HypB/UreG, nucleotide-binding domain
PF07683 - Cobalamin synthesis protein cobW C-terminal domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
90002 - Hypothetical protein YjiA, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q8IUF1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005524 ATP binding


-  Descriptions from all associated GenBank mRNAs
  AK290072 - Homo sapiens cDNA FLJ75607 complete cds, highly similar to Homo sapiens COBW domain containing 2 (CBWD2), mRNA.
JD029876 - Sequence 10900 from Patent EP1572962.
AK303653 - Homo sapiens cDNA FLJ50340 complete cds, highly similar to COBW domain-containing protein 1.
AF257330 - Homo sapiens dopamine-responsive protein mRNA, complete cds.
AY343910 - Homo sapiens COBW domain containing protein 2 (CBWD2) mRNA, complete cds.
AY320414 - Homo sapiens nasopharyngeal carcinoma-associated antigen NPC-A-6 mRNA, complete cds.
BC120991 - Homo sapiens COBW domain containing 2, mRNA (cDNA clone MGC:149578 IMAGE:40116409), complete cds.
BC120992 - Homo sapiens COBW domain containing 2, mRNA (cDNA clone MGC:149579 IMAGE:40116411), complete cds.
AK225251 - Homo sapiens mRNA for COBW domain containing 1 variant, clone: DMC02881.
AF452722 - Homo sapiens COBW domain-containing protein mRNA, complete cds.
KJ900276 - Synthetic construct Homo sapiens clone ccsbBroadEn_09670 CBWD2 gene, encodes complete protein.
KJ905626 - Synthetic construct Homo sapiens clone ccsbBroadEn_15265 CBWD2 gene, encodes complete protein.
AK124867 - Homo sapiens cDNA FLJ42877 fis, clone BRHIP2029393, highly similar to Homo sapiens COBW-like protein.
JD566734 - Sequence 547758 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CBWD2_HUMAN, NM_172003, NP_742000, Q0VAN3, Q8IUF1
UCSC ID: uc002tju.3
RefSeq Accession: NM_172003
Protein: Q8IUF1 (aka CBWD2_HUMAN)
CCDS: CCDS2116.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_172003.3
exon count: 15CDS single in 3' UTR: no RNA size: 1827
ORF size: 1188CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2484.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.