Human Gene ZNF764 (uc002dyq.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 764 (ZNF764), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:30,565,085-30,569,642 Size: 4,558 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr16:30,566,515-30,569,503 Size: 2,989 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:30,565,085-30,569,642)mRNA (may differ from genome)Protein (408 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 764;
FUNCTION: May be involved in transcriptional regulation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 7 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF764
Diseases sorted by gene-association score: thyroid hormone resistance (11)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.16 RPKM in Testis
Total median expression: 173.06 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.80139-0.459 Picture PostScript Text
3' UTR -478.401430-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q96H86
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  BC000016 - Homo sapiens zinc finger protein 764, mRNA (cDNA clone IMAGE:3508146), partial cds.
BC008821 - Homo sapiens zinc finger protein 764, mRNA (cDNA clone MGC:13138 IMAGE:4130947), complete cds.
JD045760 - Sequence 26784 from Patent EP1572962.
JD206451 - Sequence 187475 from Patent EP1572962.
JD540263 - Sequence 521287 from Patent EP1572962.
JD324566 - Sequence 305590 from Patent EP1572962.
JD147093 - Sequence 128117 from Patent EP1572962.
JD345203 - Sequence 326227 from Patent EP1572962.
JD086752 - Sequence 67776 from Patent EP1572962.
JD348765 - Sequence 329789 from Patent EP1572962.
JD490446 - Sequence 471470 from Patent EP1572962.
JD206683 - Sequence 187707 from Patent EP1572962.
AK093992 - Homo sapiens cDNA FLJ36673 fis, clone UTERU2004163, weakly similar to Zinc finger protein 688.
AX748400 - Sequence 1925 from Patent EP1308459.
JD518448 - Sequence 499472 from Patent EP1572962.
JD351295 - Sequence 332319 from Patent EP1572962.
JD318041 - Sequence 299065 from Patent EP1572962.
JD369221 - Sequence 350245 from Patent EP1572962.
JD369220 - Sequence 350244 from Patent EP1572962.
JD293311 - Sequence 274335 from Patent EP1572962.
JD229137 - Sequence 210161 from Patent EP1572962.
JD281690 - Sequence 262714 from Patent EP1572962.
JD232944 - Sequence 213968 from Patent EP1572962.
JD549103 - Sequence 530127 from Patent EP1572962.
DQ588234 - Homo sapiens piRNA piR-55346, complete sequence.
JD341407 - Sequence 322431 from Patent EP1572962.
JD505999 - Sequence 487023 from Patent EP1572962.
JD285553 - Sequence 266577 from Patent EP1572962.
JD163846 - Sequence 144870 from Patent EP1572962.
JD213691 - Sequence 194715 from Patent EP1572962.
JD521766 - Sequence 502790 from Patent EP1572962.
JD245798 - Sequence 226822 from Patent EP1572962.
JD505650 - Sequence 486674 from Patent EP1572962.
JD536105 - Sequence 517129 from Patent EP1572962.
JD059811 - Sequence 40835 from Patent EP1572962.
JD196790 - Sequence 177814 from Patent EP1572962.
JD069562 - Sequence 50586 from Patent EP1572962.
JD541342 - Sequence 522366 from Patent EP1572962.
JD072966 - Sequence 53990 from Patent EP1572962.
JD265963 - Sequence 246987 from Patent EP1572962.
JD072741 - Sequence 53765 from Patent EP1572962.
JD558162 - Sequence 539186 from Patent EP1572962.
JD269808 - Sequence 250832 from Patent EP1572962.
JD323584 - Sequence 304608 from Patent EP1572962.
JD165488 - Sequence 146512 from Patent EP1572962.
JD446492 - Sequence 427516 from Patent EP1572962.
JD407307 - Sequence 388331 from Patent EP1572962.
JD057821 - Sequence 38845 from Patent EP1572962.
JD231505 - Sequence 212529 from Patent EP1572962.
JD331700 - Sequence 312724 from Patent EP1572962.
JF432713 - Synthetic construct Homo sapiens clone IMAGE:100073953 zinc finger protein 764 (ZNF764) gene, encodes complete protein.
KJ899950 - Synthetic construct Homo sapiens clone ccsbBroadEn_09344 ZNF764 gene, encodes complete protein.
EU446557 - Synthetic construct Homo sapiens clone IMAGE:100070243; IMAGE:100011766; FLH257354.01L zinc finger protein 764 (ZNF764) gene, encodes complete protein.
DQ574270 - Homo sapiens piRNA piR-42382, complete sequence.
JD382979 - Sequence 364003 from Patent EP1572962.
DQ577011 - Homo sapiens piRNA piR-45123, complete sequence.
JD406458 - Sequence 387482 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96H86 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8MZF4, NM_033410, NP_219363, Q96H86, Q9BWS1, ZN764_HUMAN
UCSC ID: uc002dyq.3
RefSeq Accession: NM_033410
Protein: Q96H86 (aka ZN764_HUMAN)
CCDS: CCDS10683.1, CCDS54001.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_033410.3
exon count: 3CDS single in 3' UTR: no RNA size: 2817
ORF size: 1227CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2651.00frame shift in genome: no % Coverage: 99.25
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.