Human Gene ZNF605 (uc001uli.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 605 (ZNF605), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:133,498,019-133,532,892 Size: 34,874 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr12:133,501,959-133,522,221 Size: 20,263 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr12:133,498,019-133,532,892)mRNA (may differ from genome)Protein (672 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF605
CDC HuGE Published Literature: ZNF605
Positive Disease Associations: Erythrocytes
Related Studies:
  1. Erythrocytes
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.69 RPKM in Brain - Cerebellum
Total median expression: 184.29 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -70.27226-0.311 Picture PostScript Text
3' UTR -1074.593940-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q86T29-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AL832623 - Homo sapiens mRNA; cDNA DKFZp451B1818 (from clone DKFZp451B1818); complete cds.
AK027873 - Homo sapiens cDNA FLJ14967 fis, clone THYRO1000242, moderately similar to ZINC FINGER PROTEIN 84.
AL832191 - Homo sapiens mRNA; cDNA DKFZp686B222 (from clone DKFZp686B222); complete cds.
AK122878 - Homo sapiens cDNA FLJ16520 fis, clone NT2RI3007878, highly similar to Zinc finger protein 605.
JD437494 - Sequence 418518 from Patent EP1572962.
JD114208 - Sequence 95232 from Patent EP1572962.
JD538918 - Sequence 519942 from Patent EP1572962.
JD209964 - Sequence 190988 from Patent EP1572962.
JD048919 - Sequence 29943 from Patent EP1572962.
JD379123 - Sequence 360147 from Patent EP1572962.
JD307252 - Sequence 288276 from Patent EP1572962.
JD313625 - Sequence 294649 from Patent EP1572962.
JD261167 - Sequence 242191 from Patent EP1572962.
JD376979 - Sequence 358003 from Patent EP1572962.
JD479240 - Sequence 460264 from Patent EP1572962.
JD296218 - Sequence 277242 from Patent EP1572962.
DQ573365 - Homo sapiens piRNA piR-41477, complete sequence.
JD555559 - Sequence 536583 from Patent EP1572962.
JD056502 - Sequence 37526 from Patent EP1572962.
JD285893 - Sequence 266917 from Patent EP1572962.
JD289652 - Sequence 270676 from Patent EP1572962.
JD090572 - Sequence 71596 from Patent EP1572962.
JD488406 - Sequence 469430 from Patent EP1572962.
JD483211 - Sequence 464235 from Patent EP1572962.
JD323986 - Sequence 305010 from Patent EP1572962.
JD317333 - Sequence 298357 from Patent EP1572962.
JD062589 - Sequence 43613 from Patent EP1572962.
JD061534 - Sequence 42558 from Patent EP1572962.
JD435783 - Sequence 416807 from Patent EP1572962.
JD158684 - Sequence 139708 from Patent EP1572962.
JD082384 - Sequence 63408 from Patent EP1572962.
JD502101 - Sequence 483125 from Patent EP1572962.
JD410992 - Sequence 392016 from Patent EP1572962.
JD538982 - Sequence 520006 from Patent EP1572962.
JD206123 - Sequence 187147 from Patent EP1572962.
JD172415 - Sequence 153439 from Patent EP1572962.
JD187500 - Sequence 168524 from Patent EP1572962.
JD370522 - Sequence 351546 from Patent EP1572962.
JD469118 - Sequence 450142 from Patent EP1572962.
JD555399 - Sequence 536423 from Patent EP1572962.
JD082507 - Sequence 63531 from Patent EP1572962.
JD060263 - Sequence 41287 from Patent EP1572962.
JD036582 - Sequence 17606 from Patent EP1572962.
JD347772 - Sequence 328796 from Patent EP1572962.
JD167547 - Sequence 148571 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
BC062737 - Homo sapiens cDNA clone IMAGE:30330029, partial cds.
BC020877 - Homo sapiens zinc finger protein 605, mRNA (cDNA clone IMAGE:4612147), partial cds.
JD440677 - Sequence 421701 from Patent EP1572962.
JD319050 - Sequence 300074 from Patent EP1572962.
JD491363 - Sequence 472387 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86T29 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001164715, NP_001158187, Q86T29-2
UCSC ID: uc001uli.3
RefSeq Accession: NM_001164715
Protein: Q86T29-2, splice isoform of Q86T29 CCDS: CCDS31938.1, CCDS53850.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001164715.1
exon count: 5CDS single in 3' UTR: no RNA size: 6196
ORF size: 2019CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3950.00frame shift in genome: no % Coverage: 99.82
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.