Human Gene GAGE12D (uc004dog.4) Description and Page Index
  Description: Homo sapiens G antigen 12D (GAGE12D), mRNA.
RefSeq Summary (NM_001477): This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF055474.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chrX:49,334,992-49,342,370 Size: 7,379 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chrX:49,336,158-49,342,266 Size: 6,109 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:49,334,992-49,342,370)mRNA (may differ from genome)Protein (117 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=G antigen 7; Short=GAGE-7; AltName: Full=AL4; AltName: Full=Cancer/testis antigen 4.7; Short=CT4.7; AltName: Full=GAGE-12I; AltName: Full=GAGE-7B; AltName: Full=GAGE-8;
TISSUE SPECIFICITY: Expressed in some prostate cancer tissues but not in normal prostate tissue.
MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.
SIMILARITY: Belongs to the GAGE family.
CAUTION: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.81 RPKM in Testis
Total median expression: 0.81 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.10127-0.331 Picture PostScript Text
3' UTR -21.20104-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008625 - GAGE

Pfam Domains:
PF05831 - GAGE protein

ModBase Predicted Comparative 3D Structure on O76087
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component

-  Descriptions from all associated GenBank mRNAs
  BC005363 - Homo sapiens G antigen 1, mRNA (cDNA clone IMAGE:3686872), partial cds.
BC024914 - Homo sapiens G antigen 5, mRNA (cDNA clone MGC:21275 IMAGE:4471969), complete cds.
U19145 - Human GAGE-4 protein mRNA, complete cds.
BC143619 - Homo sapiens G antigen 12B, mRNA (cDNA clone MGC:177149 IMAGE:9052132), complete cds.
BC104951 - Homo sapiens G antigen 12I, mRNA (cDNA clone MGC:132611 IMAGE:8143954), complete cds.
BC130374 - Homo sapiens G antigen 12B, mRNA (cDNA clone MGC:163246 IMAGE:40146405), complete cds.
BC143615 - Homo sapiens G antigen 12B, mRNA (cDNA clone MGC:177145 IMAGE:9052128), complete cds.
U19147 - Human GAGE-6 protein mRNA, complete cds.
AF058988 - Homo sapiens melanoma antigen related GAGE-7 mRNA, complete cds.
U19146 - Human GAGE-5 protein mRNA, complete cds.
BC031628 - Homo sapiens G antigen 12I, mRNA (cDNA clone MGC:34597 IMAGE:5168892), complete cds.
BC081536 - Homo sapiens G antigen 7, transcript variant 2, mRNA (cDNA clone MGC:105124 IMAGE:30524801), complete cds.
AF055474 - Homo sapiens GAGE-7B mRNA, complete cds.
BC121182 - Homo sapiens G antigen 12I, mRNA (cDNA clone MGC:150598 IMAGE:40123253), complete cds.
BC121183 - Homo sapiens G antigen 12I, mRNA (cDNA clone MGC:150599 IMAGE:40123261), complete cds.
BC144193 - Homo sapiens G antigen 7, mRNA (cDNA clone MGC:177730 IMAGE:9052713), complete cds.
CR542236 - Homo sapiens full open reading frame cDNA clone RZPDo834H0625D for gene GAGE5, G antigen 5; complete cds, without stopcodon.
BC148435 - Synthetic construct Homo sapiens clone IMAGE:100015388, MGC:183016 G antigen 6 (GAGE6) mRNA, encodes complete protein.
HQ258058 - Synthetic construct Homo sapiens clone IMAGE:100072367 G antigen 12E (GAGE12E) gene, encodes complete protein.
KJ896342 - Synthetic construct Homo sapiens clone ccsbBroadEn_05736 GAGE12B gene, encodes complete protein.
KJ891216 - Synthetic construct Homo sapiens clone ccsbBroadEn_00610 GAGE5 gene, encodes complete protein.
DQ891160 - Synthetic construct clone IMAGE:100003790; FLH170720.01X; RZPDo839A10100D G antigen 5 (GAGE5) gene, encodes complete protein.
KJ904717 - Synthetic construct Homo sapiens clone ccsbBroadEn_14111 GAGE12I gene, encodes complete protein.
BC069086 - Homo sapiens G antigen 7, mRNA (cDNA clone IMAGE:7216900), partial cds.
DQ579008 - Homo sapiens piRNA piR-47120, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZM13, GAGE12I, GAGE7, GAGE7B, GAGE7_HUMAN, NM_001477, NP_001468, O76087, Q4V324
UCSC ID: uc004dog.4
RefSeq Accession: NM_001477
Protein: O76087 (aka GAGE7_HUMAN or GGE7_HUMAN)
CCDS: CCDS43947.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001477.1
exon count: 5CDS single in 3' UTR: no RNA size: 526
ORF size: 354CDS single in intron: no Alignment % ID: 99.80
txCdsPredict score: 881.00frame shift in genome: no % Coverage: 95.44
has start codon: yes stop codon in genome: no # of Alignments: 3
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.