Human Gene GAGE12D (uc004dog.4) Description and Page Index
Description: Homo sapiens G antigen 12D (GAGE12D), mRNA. RefSeq Summary (NM_001477): This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AF055474.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:49,334,992-49,342,370 Size: 7,379 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chrX:49,336,158-49,342,266 Size: 6,109 Coding Exon Count: 4
ID:GAGE7_HUMAN DESCRIPTION: RecName: Full=G antigen 7; Short=GAGE-7; AltName: Full=AL4; AltName: Full=Cancer/testis antigen 4.7; Short=CT4.7; AltName: Full=GAGE-12I; AltName: Full=GAGE-7B; AltName: Full=GAGE-8; TISSUE SPECIFICITY: Expressed in some prostate cancer tissues but not in normal prostate tissue. MISCELLANEOUS: This gene belongs to a family of genes organized in clustered repeats. They have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells. SIMILARITY: Belongs to the GAGE family. CAUTION: The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 0.81 RPKM in Testis
Total median expression: 0.81 RPKM
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O76087
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary