Human Gene CIB3 (uc002nds.3) Description and Page Index
  Description: Homo sapiens calcium and integrin binding family member 3 (CIB3), mRNA.
RefSeq Summary (NM_054113): This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Transcript (Including UTRs)
   Position: hg19 chr19:16,272,179-16,284,286 Size: 12,108 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:16,272,276-16,284,286 Size: 12,011 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:16,272,179-16,284,286)mRNA (may differ from genome)Protein (187 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CIB3_HUMAN
DESCRIPTION: RecName: Full=Calcium and integrin-binding family member 3; AltName: Full=Kinase-interacting protein 3; Short=KIP 3;
SIMILARITY: Contains 3 EF-hand domains.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CIB3
CDC HuGE Published Literature: CIB3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.76 RPKM in Testis
Total median expression: 0.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -33.1097-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF13202 - EF hand
PF13499 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on Q96Q77
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  AB050868 - Homo sapiens mRNA for KIP3, complete cds.
BC113591 - Homo sapiens calcium and integrin binding family member 3, mRNA (cDNA clone MGC:142151 IMAGE:8322643), complete cds.
BC112200 - Homo sapiens calcium and integrin binding family member 3, mRNA (cDNA clone MGC:138405 IMAGE:8327668), complete cds.
BC069320 - Homo sapiens calcium and integrin binding family member 3, mRNA (cDNA clone IMAGE:7262119), complete cds.
BC069428 - Homo sapiens calcium and integrin binding family member 3, mRNA (cDNA clone MGC:96922 IMAGE:7262131), complete cds.
BC069524 - Homo sapiens calcium and integrin binding family member 3, mRNA (cDNA clone IMAGE:7262143), partial cds.
JD115234 - Sequence 96258 from Patent EP1572962.
HQ258101 - Synthetic construct Homo sapiens clone IMAGE:100072410 calcium and integrin binding family member 3 (CIB3) gene, encodes complete protein.
KJ900055 - Synthetic construct Homo sapiens clone ccsbBroadEn_09449 CIB3 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: CIB3_HUMAN, KIP3, NM_054113, NP_473454, Q2M1W0, Q96Q77
UCSC ID: uc002nds.3
RefSeq Accession: NM_054113
Protein: Q96Q77 (aka CIB3_HUMAN)
CCDS: CCDS12340.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_054113.2
exon count: 6CDS single in 3' UTR: no RNA size: 661
ORF size: 564CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1328.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.