Human Gene MAGEB3 (uc004dca.2) Description and Page Index
Description: Homo sapiens melanoma antigen family B, 3 (MAGEB3), mRNA. RefSeq Summary (NM_002365): This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK057441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:30,248,553-30,255,610 Size: 7,058 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chrX:30,254,042-30,255,082 Size: 1,041 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01454 - MAGE family PF12440 - Melanoma associated antigen family N terminal
ModBase Predicted Comparative 3D Structure on O15480
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK057441 - Homo sapiens cDNA FLJ32879 fis, clone TESTI2004119, highly similar to MELANOMA-ASSOCIATED ANTIGEN B3. BC069784 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:97346 IMAGE:7262601), complete cds. JD099769 - Sequence 80793 from Patent EP1572962. JD402778 - Sequence 383802 from Patent EP1572962. BC126320 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:161598 IMAGE:8992036), complete cds. BC126322 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:161600 IMAGE:8992038), complete cds. BC074756 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:103833 IMAGE:30915215), complete cds. JD467537 - Sequence 448561 from Patent EP1572962. AB463875 - Synthetic construct DNA, clone: pF1KB7146, Homo sapiens MAGEB3 gene for melanoma antigen family B, 3, without stop codon, in Flexi system. HQ258181 - Synthetic construct Homo sapiens clone IMAGE:100072490 melanoma antigen family B, 3 (MAGEB3) (MAGEB3) gene, encodes complete protein. KJ897161 - Synthetic construct Homo sapiens clone ccsbBroadEn_06555 MAGEB3 gene, encodes complete protein. KJ905822 - Synthetic construct Homo sapiens clone ccsbBroadEn_15492 MAGEB3 gene, encodes complete protein. HQ447491 - Synthetic construct Homo sapiens clone IMAGE:100070824; CCSB014030_01 melanoma antigen family B, 3 (MAGEB3) gene, encodes complete protein. JD068470 - Sequence 49494 from Patent EP1572962. JD530416 - Sequence 511440 from Patent EP1572962. JD552463 - Sequence 533487 from Patent EP1572962. JD089255 - Sequence 70279 from Patent EP1572962.