Human Gene MAGEB3 (uc004dca.2) Description and Page Index
  Description: Homo sapiens melanoma antigen family B, 3 (MAGEB3), mRNA.
RefSeq Summary (NM_002365): This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: AK057441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chrX:30,248,553-30,255,610 Size: 7,058 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chrX:30,254,042-30,255,082 Size: 1,041 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:30,248,553-30,255,610)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MAGB3_HUMAN
DESCRIPTION: RecName: Full=Melanoma-associated antigen B3; AltName: Full=MAGE-B3 antigen;
TISSUE SPECIFICITY: Expressed in testis.
SIMILARITY: Contains 1 MAGE domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: MAGEB3
Diseases sorted by gene-association score: melanoma (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.75 RPKM in Testis
Total median expression: 3.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -284.71737-0.386 Picture PostScript Text
3' UTR -110.50528-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002190 - MAGE
IPR021072 - Melanoma_ass_antigen_N

Pfam Domains:
PF01454 - MAGE family
PF12440 - Melanoma associated antigen family N terminal

ModBase Predicted Comparative 3D Structure on O15480
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK057441 - Homo sapiens cDNA FLJ32879 fis, clone TESTI2004119, highly similar to MELANOMA-ASSOCIATED ANTIGEN B3.
BC069784 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:97346 IMAGE:7262601), complete cds.
JD099769 - Sequence 80793 from Patent EP1572962.
JD402778 - Sequence 383802 from Patent EP1572962.
BC126320 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:161598 IMAGE:8992036), complete cds.
BC126322 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:161600 IMAGE:8992038), complete cds.
BC074756 - Homo sapiens melanoma antigen family B, 3, mRNA (cDNA clone MGC:103833 IMAGE:30915215), complete cds.
JD467537 - Sequence 448561 from Patent EP1572962.
AB463875 - Synthetic construct DNA, clone: pF1KB7146, Homo sapiens MAGEB3 gene for melanoma antigen family B, 3, without stop codon, in Flexi system.
HQ258181 - Synthetic construct Homo sapiens clone IMAGE:100072490 melanoma antigen family B, 3 (MAGEB3) (MAGEB3) gene, encodes complete protein.
KJ897161 - Synthetic construct Homo sapiens clone ccsbBroadEn_06555 MAGEB3 gene, encodes complete protein.
KJ905822 - Synthetic construct Homo sapiens clone ccsbBroadEn_15492 MAGEB3 gene, encodes complete protein.
HQ447491 - Synthetic construct Homo sapiens clone IMAGE:100070824; CCSB014030_01 melanoma antigen family B, 3 (MAGEB3) gene, encodes complete protein.
JD068470 - Sequence 49494 from Patent EP1572962.
JD530416 - Sequence 511440 from Patent EP1572962.
JD552463 - Sequence 533487 from Patent EP1572962.
JD089255 - Sequence 70279 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0AVE4, B3KQ52, MAGB3_HUMAN, NM_002365, NP_002356, O15480, O75861
UCSC ID: uc004dca.2
RefSeq Accession: NM_002365
Protein: O15480 (aka MAGB3_HUMAN or MGB3_HUMAN)
CCDS: CCDS14220.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002365.4
exon count: 5CDS single in 3' UTR: no RNA size: 2310
ORF size: 1041CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 1738.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.