Human Gene POTED (uc002yjb.1) Description and Page Index
  Description: Homo sapiens POTE ankyrin domain family, member D (POTED), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr21:14,982,498-15,013,906 Size: 31,409 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr21:14,982,550-15,013,887 Size: 31,338 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr21:14,982,498-15,013,906)mRNA (may differ from genome)Protein (584 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=POTE ankyrin domain family member D; AltName: Full=ANKRD26-like family B member 3; AltName: Full=Ankyrin repeat domain-containing protein 21; AltName: Full=Prostate, ovary, testis-expressed protein; Short=Protein POTE;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.
SIMILARITY: Belongs to the POTE family.
SIMILARITY: Contains 6 ANK repeats.

-  MalaCards Disease Associations
  MalaCards Gene Search: POTED
Diseases sorted by gene-association score: holoprosencephaly 3 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
  • D019327 Copper Sulfate
  • C006253 pirinixic acid

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.18 RPKM in Testis
Total median expression: 4.18 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.8052-0.323 Picture PostScript Text
3' UTR 0.00190.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF14915 - CCDC144C protein coiled-coil region

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q86YR6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane

-  Descriptions from all associated GenBank mRNAs
  KJ906489 - Synthetic construct Homo sapiens clone ccsbBroadEn_16159 POTEB gene, encodes complete protein.
AY172978 - Homo sapiens POTE mRNA, complete cds.
AY465173 - Homo sapiens POTE15A mRNA, complete cds, alternatively spliced.
BC166701 - Synthetic construct Homo sapiens clone IMAGE:100066427, MGC:195564 POTE ankyrin domain family, member D (POTED) mRNA, encodes complete protein.
JD315124 - Sequence 296148 from Patent EP1572962.
JD289498 - Sequence 270522 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A26B3, ANKRD21, C9JCF7, NM_174981, NP_778146, POTE, POTED_HUMAN, Q86YR6
UCSC ID: uc002yjb.1
RefSeq Accession: NM_174981
Protein: Q86YR6 (aka POTED_HUMAN)
CCDS: CCDS13562.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_174981.3
exon count: 11CDS single in 3' UTR: no RNA size: 1826
ORF size: 1755CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2505.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.