Human Gene EXOC7 (uc010wsw.2) Description and Page Index
  Description: Homo sapiens exocyst complex component 7 (EXOC7), transcript variant 6, mRNA.
RefSeq Summary (NM_001145299): The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].
Transcript (Including UTRs)
   Position: hg19 chr17:74,077,086-74,099,868 Size: 22,783 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr17:74,079,729-74,099,773 Size: 20,045 Coding Exon Count: 20 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:74,077,086-74,099,868)mRNA (may differ from genome)Protein (707 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: EXOC7
Diseases sorted by gene-association score: eastern equine encephalitis (8), bardet-biedl syndrome 18 (7), bardet-biedl syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.90 RPKM in Thyroid
Total median expression: 952.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.5095-0.395 Picture PostScript Text
3' UTR -1181.302643-0.447 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF03081 - Exo70 exocyst complex subunit

ModBase Predicted Comparative 3D Structure on Q9UPT5-6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Descriptions from all associated GenBank mRNAs
  AK000718 - Homo sapiens cDNA FLJ20711 fis, clone HUV01082.
BC015165 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone IMAGE:3891713), complete cds.
AK022552 - Homo sapiens cDNA FLJ12490 fis, clone NT2RM2001592, highly similar to Rattus norvegicus rexo70 mRNA.
AK023832 - Homo sapiens cDNA FLJ13770 fis, clone PLACE4000269, highly similar to Rattus norvegicus rexo70 mRNA.
AB028990 - Homo sapiens KIAA1067 mRNA for KIAA1067 protein.
AL162005 - Homo sapiens mRNA; cDNA DKFZp434D2029 (from clone DKFZp434D2029).
BX648435 - Homo sapiens mRNA; cDNA DKFZp686J04253 (from clone DKFZp686J04253).
AK128278 - Homo sapiens cDNA FLJ46415 fis, clone THYMU3011717, moderately similar to Mus musculus EXO70 protein (Exo70) mRNA.
JD544409 - Sequence 525433 from Patent EP1572962.
JD307748 - Sequence 288772 from Patent EP1572962.
AK024769 - Homo sapiens cDNA: FLJ21116 fis, clone CAS05539.
KJ902315 - Synthetic construct Homo sapiens clone ccsbBroadEn_11709 EXOC7 gene, encodes complete protein.
JD344171 - Sequence 325195 from Patent EP1572962.
JD443923 - Sequence 424947 from Patent EP1572962.
JD040016 - Sequence 21040 from Patent EP1572962.
JD496655 - Sequence 477679 from Patent EP1572962.
CU677223 - Synthetic construct Homo sapiens gateway clone IMAGE:100016850 5' read EXOC7 mRNA.
JD221051 - Sequence 202075 from Patent EP1572962.
JD545302 - Sequence 526326 from Patent EP1572962.
JD480889 - Sequence 461913 from Patent EP1572962.
JD473506 - Sequence 454530 from Patent EP1572962.
JD485375 - Sequence 466399 from Patent EP1572962.
JD060762 - Sequence 41786 from Patent EP1572962.
JD041774 - Sequence 22798 from Patent EP1572962.
JD502530 - Sequence 483554 from Patent EP1572962.
JD231176 - Sequence 212200 from Patent EP1572962.
JD418690 - Sequence 399714 from Patent EP1572962.
JD335941 - Sequence 316965 from Patent EP1572962.
JD387486 - Sequence 368510 from Patent EP1572962.
JD045648 - Sequence 26672 from Patent EP1572962.
JD317912 - Sequence 298936 from Patent EP1572962.
JD204722 - Sequence 185746 from Patent EP1572962.
JD089431 - Sequence 70455 from Patent EP1572962.
JD298797 - Sequence 279821 from Patent EP1572962.
JD372234 - Sequence 353258 from Patent EP1572962.
JD487024 - Sequence 468048 from Patent EP1572962.
BC018466 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone MGC:9876 IMAGE:3867492), complete cds.
BX647763 - Homo sapiens mRNA; cDNA DKFZp686P1551 (from clone DKFZp686P1551).
JD068885 - Sequence 49909 from Patent EP1572962.
JD354479 - Sequence 335503 from Patent EP1572962.
JD504703 - Sequence 485727 from Patent EP1572962.
JD187111 - Sequence 168135 from Patent EP1572962.
JD232973 - Sequence 213997 from Patent EP1572962.
JD249147 - Sequence 230171 from Patent EP1572962.
JD330177 - Sequence 311201 from Patent EP1572962.
JD131210 - Sequence 112234 from Patent EP1572962.
JD314048 - Sequence 295072 from Patent EP1572962.
JD227949 - Sequence 208973 from Patent EP1572962.
JD216381 - Sequence 197405 from Patent EP1572962.
JD389103 - Sequence 370127 from Patent EP1572962.
JD432306 - Sequence 413330 from Patent EP1572962.
JD365960 - Sequence 346984 from Patent EP1572962.
JD121821 - Sequence 102845 from Patent EP1572962.
JD123320 - Sequence 104344 from Patent EP1572962.
JD500346 - Sequence 481370 from Patent EP1572962.
JD471454 - Sequence 452478 from Patent EP1572962.
JD074960 - Sequence 55984 from Patent EP1572962.
JD497986 - Sequence 479010 from Patent EP1572962.
JD297694 - Sequence 278718 from Patent EP1572962.
JD166856 - Sequence 147880 from Patent EP1572962.
JD266372 - Sequence 247396 from Patent EP1572962.
JD382530 - Sequence 363554 from Patent EP1572962.
JD068296 - Sequence 49320 from Patent EP1572962.
JD242317 - Sequence 223341 from Patent EP1572962.
JD517195 - Sequence 498219 from Patent EP1572962.
JD127119 - Sequence 108143 from Patent EP1572962.
JD200648 - Sequence 181672 from Patent EP1572962.
JD525527 - Sequence 506551 from Patent EP1572962.
JD226712 - Sequence 207736 from Patent EP1572962.
JD057294 - Sequence 38318 from Patent EP1572962.
AK295871 - Homo sapiens cDNA FLJ58532 complete cds, highly similar to Exocyst complex component 7.
JD278540 - Sequence 259564 from Patent EP1572962.
JD233521 - Sequence 214545 from Patent EP1572962.
AK098284 - Homo sapiens cDNA FLJ40965 fis, clone UTERU2012031, moderately similar to Rattus norvegicus rexo70 mRNA.
AY869728 - Homo sapiens 2-5-3p (EXOC7) mRNA, partial cds.
BC011045 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone MGC:16883 IMAGE:4215228), complete cds.
AL834324 - Homo sapiens mRNA; cDNA DKFZp564B1282 (from clone DKFZp564B1282).
JD051184 - Sequence 32208 from Patent EP1572962.
JD027724 - Sequence 8748 from Patent EP1572962.
JD019812 - Sequence 836 from Patent EP1572962.
JD298044 - Sequence 279068 from Patent EP1572962.
FJ457119 - Homo sapiens EXOC7 splice variant 5 (EXOC7) mRNA, complete cds, alternatively spliced.
FJ457120 - Homo sapiens EXOC7 splice variant 6 (EXOC7) mRNA, complete cds, alternatively spliced.
AB384100 - Synthetic construct DNA, clone: pF1KSDA1067, Homo sapiens EXOC7 gene for exocyst complex component 7, complete cds, without stop codon, in Flexi system.
AK022397 - Homo sapiens cDNA FLJ12335 fis, clone MAMMA1002219, highly similar to Rattus norvegicus rexo70 mRNA.
BC029432 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone IMAGE:4093432), with apparent retained intron.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04910 - Insulin signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q9UPT5 (Reactome details) participates in the following event(s):

R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex
R-HSA-264876 Insulin processing
R-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-2980736 Peptide hormone metabolism
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-199991 Membrane Trafficking
R-HSA-392499 Metabolism of proteins
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: EXO70, KIAA1067, NM_001145299, NP_001138771, Q9UPT5-6
UCSC ID: uc010wsw.2
RefSeq Accession: NM_001145299
Protein: Q9UPT5-6, splice isoform of Q9UPT5 CCDS: CCDS32738.1, CCDS45781.1, CCDS45782.1, CCDS45783.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001145299.2
exon count: 20CDS single in 3' UTR: no RNA size: 4868
ORF size: 2124CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4448.00frame shift in genome: no % Coverage: 99.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.