Human Gene KLC1 (uc010tyf.2) Description and Page Index
  Description: Homo sapiens kinesin light chain 1 (KLC1), transcript variant 3, mRNA.
RefSeq Summary (NM_001130107): Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr14:104,095,525-104,167,888 Size: 72,364 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr14:104,120,902-104,167,540 Size: 46,639 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:104,095,525-104,167,888)mRNA (may differ from genome)Protein (618 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8VTM4_HUMAN
DESCRIPTION: SubName: Full=Kinesin light chain 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KLC1
CDC HuGE Published Literature: KLC1

-  MalaCards Disease Associations
  MalaCards Gene Search: KLC1
Diseases sorted by gene-association score: medulloblastoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.00 RPKM in Nerve - Tibial
Total median expression: 967.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -173.20308-0.562 Picture PostScript Text
3' UTR -145.46348-0.418 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002151 - Kinesin_light
IPR015792 - Kinesin_light_repeat
IPR015390 - Rabaptin_Rab5-bd_dom
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF00515 - Tetratricopeptide repeat
PF01535 - PPR repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13374 - Tetratricopeptide repeat
PF13424 - Tetratricopeptide repeat
PF13432 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on F8VTM4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK299527 - Homo sapiens cDNA FLJ55519 complete cds, highly similar to Kinesin light chain 1.
AK294508 - Homo sapiens cDNA FLJ61233 complete cds, highly similar to Kinesin light chain 1.
BC008881 - Homo sapiens kinesin light chain 1, mRNA (cDNA clone MGC:15245 IMAGE:4301579), complete cds.
L04733 - Homo sapiens kinesin light chain mRNA, complete cds.
AF527736 - Homo sapiens medulloblastoma antigen MU-MB-2.50 mRNA, partial cds.
AY180164 - Homo sapiens kinesin light chain 1C (KNS2) mRNA, complete cds.
JD026390 - Sequence 7414 from Patent EP1572962.
JD423274 - Sequence 404298 from Patent EP1572962.
JD508673 - Sequence 489697 from Patent EP1572962.
JD060225 - Sequence 41249 from Patent EP1572962.
JD459798 - Sequence 440822 from Patent EP1572962.
DQ893256 - Synthetic construct clone IMAGE:100005886; FLH195673.01X; RZPDo839F01152D kinesin 2 (KNS2) gene, encodes complete protein.
DQ896585 - Synthetic construct Homo sapiens clone IMAGE:100011045; FLH195669.01L; RZPDo839F01151D kinesin 2 (KNS2) gene, encodes complete protein.
KJ891518 - Synthetic construct Homo sapiens clone ccsbBroadEn_00912 KLC1 gene, encodes complete protein.
AB385087 - Synthetic construct DNA, clone: pF1KB5346, Homo sapiens KLC1 gene for kinesin light chain 1, complete cds, without stop codon, in Flexi system.
JD510804 - Sequence 491828 from Patent EP1572962.
AB451431 - Homo sapiens KLC1 mRNA for kinesin light chain 1, partial cds, clone: FLJ08153AAAF.
AB451299 - Homo sapiens KLC1 mRNA for kinesin light chain 1, complete cds, clone: FLJ08153AAAN.
JD025691 - Sequence 6715 from Patent EP1572962.
JD033140 - Sequence 14164 from Patent EP1572962.
JD025287 - Sequence 6311 from Patent EP1572962.
JD030993 - Sequence 12017 from Patent EP1572962.
AB781674 - Homo sapiens KLC1-ALK mRNA for KLC1-ALK fusion protein, partial cds.
AY180163 - Homo sapiens kinesin light chain 1S (KNS2) mRNA, partial cds.
AY244715 - Homo sapiens kinesin light chain 1B (KNS2) mRNA, partial cds; alternatively spliced.
AY180166 - Homo sapiens kinesin light chain 1N (KNS2) mRNA, partial cds.
AY180170 - Homo sapiens kinesin light chain 1J (KNS2) mRNA, partial cds.
AY180167 - Homo sapiens kinesin light chain 1P (KNS2) mRNA, partial cds.
AY180169 - Homo sapiens kinesin light chain 1R (KNS2) mRNA, partial cds.
AY180168 - Homo sapiens kinesin light chain 1G (KNS2) mRNA, partial cds.
AY180165 - Homo sapiens kinesin light chain 1K (KNS2) mRNA, partial cds.
AK125022 - Homo sapiens cDNA FLJ43032 fis, clone BRTHA3001221.
AL133587 - Homo sapiens mRNA; cDNA DKFZp434I139 (from clone DKFZp434I139).
JD125523 - Sequence 106547 from Patent EP1572962.
JD470036 - Sequence 451060 from Patent EP1572962.
JD228725 - Sequence 209749 from Patent EP1572962.
JD532740 - Sequence 513764 from Patent EP1572962.
JD090605 - Sequence 71629 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: F8VTM4, F8VTM4_HUMAN, NM_001130107, NP_001123579
UCSC ID: uc010tyf.2
RefSeq Accession: NM_001130107
Protein: F8VTM4 CCDS: CCDS45168.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001130107.1
exon count: 16CDS single in 3' UTR: no RNA size: 2530
ORF size: 1857CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3089.00frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.