Human Gene NCOR2 (uc010tbb.2) Description and Page Index
Description: Homo sapiens nuclear receptor corepressor 2 (NCOR2), transcript variant 1, mRNA. RefSeq Summary (NM_006312): This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]. Transcript (Including UTRs) Position: hg19 chr12:124,808,957-125,052,010 Size: 243,054 Total Exon Count: 49 Strand: - Coding Region Position: hg19 chr12:124,809,948-124,979,797 Size: 169,850 Coding Exon Count: 47
ID:C9JFD3_HUMAN DESCRIPTION: SubName: Full=Nuclear receptor corepressor 2; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on C9JFD3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF113003 - Homo sapiens silencing mediator of retinoic acid and thyroid hormone receptor alpha mRNA, complete cds. AF125672 - Homo sapiens silencing mediator of retinoic acid and thyroid hormone receptor extended isoform (SMRTE) mRNA, complete cds. AY965853 - Homo sapiens SMRTE-tau mRNA, complete cds, alternatively spliced. AB463148 - Synthetic construct DNA, clone: pF1KB0999, Homo sapiens NCOR2 gene for nuclear receptor co-repressor 2, without stop codon, in Flexi system. AB209089 - Homo sapiens mRNA for nuclear receptor co-repressor 2 variant protein. BC051312 - Homo sapiens nuclear receptor co-repressor 2, mRNA (cDNA clone IMAGE:5922788), **** WARNING: chimeric clone ****. BC033087 - Homo sapiens nuclear receptor co-repressor 2, mRNA (cDNA clone IMAGE:5016291), **** WARNING: chimeric clone ****. L32841 - Homo sapiens (clone tec53) mRNA. X79269 - H.sapiens Tera-2 clone 13 embryonal carcinoma mRNA poly-A signal. BC004326 - Homo sapiens, clone IMAGE:3629785, mRNA, partial cds. U37146 - Human silencing mediator of retinoid and thyroid hormone action (SMRT) mRNA, complete cds. JD253997 - Sequence 235021 from Patent EP1572962. JD283743 - Sequence 264767 from Patent EP1572962. JD490756 - Sequence 471780 from Patent EP1572962. JD234281 - Sequence 215305 from Patent EP1572962. JD190702 - Sequence 171726 from Patent EP1572962. JD406307 - Sequence 387331 from Patent EP1572962. JD415919 - Sequence 396943 from Patent EP1572962. JD264223 - Sequence 245247 from Patent EP1572962. JD275097 - Sequence 256121 from Patent EP1572962. JD211771 - Sequence 192795 from Patent EP1572962. JD057663 - Sequence 38687 from Patent EP1572962. JD547347 - Sequence 528371 from Patent EP1572962. S83390 - T3 receptor-associating cofactor-1 [human, fetal liver, mRNA, 2930 nt]. JD193992 - Sequence 175016 from Patent EP1572962. JD406425 - Sequence 387449 from Patent EP1572962. BC109239 - Homo sapiens cDNA clone IMAGE:40015228, **** WARNING: chimeric clone ****. AK127788 - Homo sapiens cDNA FLJ45889 fis, clone OCBBF3022166. BC020427 - Homo sapiens nuclear receptor co-repressor 2, mRNA (cDNA clone IMAGE:4179307). U80750 - Homo sapiens CTG26 mRNA, partial cds. MH507335 - Homo sapiens nuclear receptor corepressor 2 splice variant (NCOR2) mRNA, partial cds, alternatively spliced.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04330 - Notch signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_egfr_smrtePathway - Map Kinase Inactivation of SMRT Corepressor h_carm-erPathway - CARM1 and Regulation of the Estrogen Receptor h_etsPathway - METS affect on Macrophage Differentiation h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_rarrxrPathway - Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells