Human Gene FNBP4 (uc009ylv.3) Description and Page Index
Description: Homo sapiens formin binding protein 4 (FNBP4), mRNA. RefSeq Summary (NM_015308): This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]. Transcript (Including UTRs) Position: hg19 chr11:47,738,069-47,788,993 Size: 50,925 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr11:47,738,974-47,788,840 Size: 49,867 Coding Exon Count: 17
ID:FNBP4_HUMAN DESCRIPTION: RecName: Full=Formin-binding protein 4; AltName: Full=Formin-binding protein 30; SUBUNIT: Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro- rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding. DOMAIN: These WW domains interact with Arg/Gly-rich-flanked Pro- rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 2 WW domains. SEQUENCE CAUTION: Sequence=BAA76858.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N3X1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.