Human Gene RBM10 (uc004dhi.3) Description and Page Index
  Description: Homo sapiens RNA binding motif protein 10 (RBM10), transcript variant 5, mRNA.
RefSeq Summary (NM_001204468): This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011].
Transcript (Including UTRs)
   Position: hg19 chrX:47,004,617-47,046,214 Size: 41,598 Total Exon Count: 24 Strand: +
Coding Region
   Position: hg19 chrX:47,004,846-47,045,998 Size: 41,153 Coding Exon Count: 24 

Page IndexSequence and LinksMalaCardsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:47,004,617-47,046,214)mRNA (may differ from genome)Protein (995 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIOMIMPubMedStanford SOURCE
TreefamUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: RBM10
Diseases sorted by gene-association score: tarp syndrome* (1378), talipes equinovarus (11), spinal cord ependymoma (9), lymphogranuloma venereum (9), spinal cord glioma (9), atrial heart septal defect (4), pierre robin syndrome (4)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.89 RPKM in Brain - Cerebellum
Total median expression: 1146.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -106.40229-0.465 Picture PostScript Text
3' UTR -82.10216-0.380 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000467 - G_patch_dom
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR001876 - Znf_RanBP2

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00641 - Zn-finger in Ran binding protein and others
PF01585 - G-patch domain
PF12656 - G-patch domain

SCOP Domains:
54928 - RNA-binding domain, RBD
90209 - Znf265, first zinc-finger domain

ModBase Predicted Comparative 3D Structure on Q7Z3D7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0042981 regulation of apoptotic process


-  Descriptions from all associated GenBank mRNAs
  BC008733 - Homo sapiens RNA binding motif protein 10, mRNA (cDNA clone MGC:997 IMAGE:3163064), complete cds.
AK000962 - Homo sapiens cDNA FLJ10100 fis, clone HEMBA1002469.
AK225175 - Homo sapiens mRNA for RNA-binding protein 10 variant, clone: CBR06542.
BC004181 - Homo sapiens RNA binding motif protein 10, mRNA (cDNA clone MGC:2794 IMAGE:2961094), complete cds.
BX537969 - Homo sapiens mRNA; cDNA DKFZp686E2459 (from clone DKFZp686E2459); complete cds.
AK292758 - Homo sapiens cDNA FLJ77202 complete cds, highly similar to Homo sapiens RNA binding motif protein 10 (RBM10), transcript variant 2, mRNA.
AL137421 - Homo sapiens mRNA; cDNA DKFZp434P072 (from clone DKFZp434P072); partial cds.
BC003089 - Homo sapiens RNA binding motif protein 10, mRNA (cDNA clone MGC:1132 IMAGE:3536058), complete cds.
JD476277 - Sequence 457301 from Patent EP1572962.
JD206056 - Sequence 187080 from Patent EP1572962.
JD206057 - Sequence 187081 from Patent EP1572962.
GQ900942 - Homo sapiens clone HEL-T-54 epididymis secretory sperm binding protein mRNA, complete cds.
D50912 - Homo sapiens mRNA for KIAA0122 gene.
JD199355 - Sequence 180379 from Patent EP1572962.
JD421278 - Sequence 402302 from Patent EP1572962.
JD560214 - Sequence 541238 from Patent EP1572962.
JD222833 - Sequence 203857 from Patent EP1572962.
AM393073 - Synthetic construct Homo sapiens clone IMAGE:100001983 for hypothetical protein (RBM10 gene).
JD392642 - Sequence 373666 from Patent EP1572962.
JD468710 - Sequence 449734 from Patent EP1572962.
JD436756 - Sequence 417780 from Patent EP1572962.
JD309811 - Sequence 290835 from Patent EP1572962.
JD454507 - Sequence 435531 from Patent EP1572962.
JD365483 - Sequence 346507 from Patent EP1572962.
JD222972 - Sequence 203996 from Patent EP1572962.
BC024153 - Homo sapiens RNA binding motif protein 10, mRNA (cDNA clone MGC:16349 IMAGE:3845258), complete cds.
CU679067 - Synthetic construct Homo sapiens gateway clone IMAGE:100017848 5' read RBM10 mRNA.
CU678364 - Synthetic construct Homo sapiens gateway clone IMAGE:100020509 5' read RBM10 mRNA.
AB383756 - Synthetic construct DNA, clone: pF1KSDA0122, Homo sapiens RBM10 gene for RNA binding motif protein 10, complete cds, without stop codon, in Flexi system.
KJ892482 - Synthetic construct Homo sapiens clone ccsbBroadEn_01876 RBM10 gene, encodes complete protein.
KJ897818 - Synthetic construct Homo sapiens clone ccsbBroadEn_07212 RBM10 gene, encodes complete protein.
KU178411 - Homo sapiens RNA binding motif protein 10 isoform 1 (RBM10) mRNA, partial cds.
KU178412 - Homo sapiens RNA binding motif protein 10 isoform 2 (RBM10) mRNA, partial cds.
LF205175 - JP 2014500723-A/12678: Polycomb-Associated Non-Coding RNAs.
AK098115 - Homo sapiens cDNA FLJ40796 fis, clone TRACH2007754, highly similar to DXS8237E PROTEIN.
LF317265 - JP 2014500723-A/124768: Polycomb-Associated Non-Coding RNAs.
BC000681 - Homo sapiens RNA binding motif protein 10, mRNA (cDNA clone IMAGE:3349287), partial cds.
LF317264 - JP 2014500723-A/124767: Polycomb-Associated Non-Coding RNAs.
AK025854 - Homo sapiens cDNA: FLJ22201 fis, clone HRC01285.
U35373 - Human DXS8237E mRNA, partial cds.
LF317263 - JP 2014500723-A/124766: Polycomb-Associated Non-Coding RNAs.
LF317262 - JP 2014500723-A/124765: Polycomb-Associated Non-Coding RNAs.
AK024839 - Homo sapiens cDNA: FLJ21186 fis, clone CAS11677.
LF317261 - JP 2014500723-A/124764: Polycomb-Associated Non-Coding RNAs.
LF317260 - JP 2014500723-A/124763: Polycomb-Associated Non-Coding RNAs.
LF317259 - JP 2014500723-A/124762: Polycomb-Associated Non-Coding RNAs.
LF317258 - JP 2014500723-A/124761: Polycomb-Associated Non-Coding RNAs.
JD286882 - Sequence 267906 from Patent EP1572962.
JD525108 - Sequence 506132 from Patent EP1572962.
JD053046 - Sequence 34070 from Patent EP1572962.
JD262398 - Sequence 243422 from Patent EP1572962.
JD209388 - Sequence 190412 from Patent EP1572962.
JD456722 - Sequence 437746 from Patent EP1572962.
JD303156 - Sequence 284180 from Patent EP1572962.
MA440752 - JP 2018138019-A/12678: Polycomb-Associated Non-Coding RNAs.
MA552842 - JP 2018138019-A/124768: Polycomb-Associated Non-Coding RNAs.
MA552841 - JP 2018138019-A/124767: Polycomb-Associated Non-Coding RNAs.
MA552840 - JP 2018138019-A/124766: Polycomb-Associated Non-Coding RNAs.
MA552839 - JP 2018138019-A/124765: Polycomb-Associated Non-Coding RNAs.
MA552838 - JP 2018138019-A/124764: Polycomb-Associated Non-Coding RNAs.
MA552837 - JP 2018138019-A/124763: Polycomb-Associated Non-Coding RNAs.
MA552836 - JP 2018138019-A/124762: Polycomb-Associated Non-Coding RNAs.
MA552835 - JP 2018138019-A/124761: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DKFZp686E2459, NM_001204468, NP_001191397, Q7Z3D7, Q7Z3D7_HUMAN
UCSC ID: uc004dhi.3
RefSeq Accession: NM_001204468
Protein: Q7Z3D7

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001204468.1
exon count: 24CDS single in 3' UTR: no RNA size: 3443
ORF size: 2988CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 6057.00frame shift in genome: no % Coverage: 99.71
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.