Human Gene BCLAF1 (uc003qgx.1) Description and Page Index
Description: Homo sapiens BCL2-associated transcription factor 1 (BCLAF1), transcript variant 1, mRNA. RefSeq Summary (NM_014739): This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:136,578,001-136,610,989 Size: 32,989 Total Exon Count: 13 Strand: - Coding Region Position: hg19 chr6:136,582,248-136,601,004 Size: 18,757 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYF8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043620 regulation of DNA-templated transcription in response to stress GO:0045892 negative regulation of transcription, DNA-templated GO:1990830 cellular response to leukemia inhibitory factor GO:2000144 positive regulation of DNA-templated transcription, initiation GO:2001022 positive regulation of response to DNA damage stimulus GO:2001244 positive regulation of intrinsic apoptotic signaling pathway