Human Gene SUPT7L (uc002rli.1) Description and Page Index
  Description: Homo sapiens suppressor of Ty 7 (S. cerevisiae)-like (SUPT7L), mRNA.
RefSeq Summary (NM_014860): SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009].
Transcript (Including UTRs)
   Position: hg19 chr2:27,873,679-27,886,449 Size: 12,771 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr2:27,876,352-27,885,059 Size: 8,708 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,873,679-27,886,449)mRNA (may differ from genome)Protein (414 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ST65G_HUMAN
DESCRIPTION: RecName: Full=STAGA complex 65 subunit gamma; AltName: Full=Adenocarcinoma antigen ART1; AltName: Full=SPTF-associated factor 65 gamma; Short=STAF65gamma; AltName: Full=Suppressor of Ty 7-like;
SUBUNIT: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed at high levels in adenocarcinomas and gliomas and low in esophageal cancers and malignant hematological disease. Also expressed at high level in the thymus, low in peripheral blood mononuclear cells, and lowest in the stomach, small intestine, and skeletal muscle.
PTM: Sumoylated.
SEQUENCE CAUTION: Sequence=BAA34484.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.82 RPKM in Pituitary
Total median expression: 1107.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.90343-0.358 Picture PostScript Text
3' UTR -687.792673-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006565 - BTP

Pfam Domains:
PF07524 - Bromodomain associated

ModBase Predicted Comparative 3D Structure on O94864
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
GO:0004402 histone acetyltransferase activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043966 histone H3 acetylation
GO:0051457 maintenance of protein location in nucleus

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030914 STAGA complex


-  Descriptions from all associated GenBank mRNAs
  AB018307 - Homo sapiens KIAA0764 mRNA for KIAA0764 protein.
LF385508 - JP 2014500723-A/193011: Polycomb-Associated Non-Coding RNAs.
JD470206 - Sequence 451230 from Patent EP1572962.
JD302752 - Sequence 283776 from Patent EP1572962.
JD182021 - Sequence 163045 from Patent EP1572962.
JD420577 - Sequence 401601 from Patent EP1572962.
JD199804 - Sequence 180828 from Patent EP1572962.
JD348125 - Sequence 329149 from Patent EP1572962.
JD553310 - Sequence 534334 from Patent EP1572962.
JD090736 - Sequence 71760 from Patent EP1572962.
JD429203 - Sequence 410227 from Patent EP1572962.
JD361702 - Sequence 342726 from Patent EP1572962.
JD239424 - Sequence 220448 from Patent EP1572962.
JD288361 - Sequence 269385 from Patent EP1572962.
JD288607 - Sequence 269631 from Patent EP1572962.
JD528522 - Sequence 509546 from Patent EP1572962.
JD532126 - Sequence 513150 from Patent EP1572962.
JD495894 - Sequence 476918 from Patent EP1572962.
JD099312 - Sequence 80336 from Patent EP1572962.
JD072163 - Sequence 53187 from Patent EP1572962.
JD099713 - Sequence 80737 from Patent EP1572962.
JD116305 - Sequence 97329 from Patent EP1572962.
JD334440 - Sequence 315464 from Patent EP1572962.
JD290249 - Sequence 271273 from Patent EP1572962.
JD530756 - Sequence 511780 from Patent EP1572962.
JD530931 - Sequence 511955 from Patent EP1572962.
JD250356 - Sequence 231380 from Patent EP1572962.
JD133623 - Sequence 114647 from Patent EP1572962.
JD089070 - Sequence 70094 from Patent EP1572962.
LF206808 - JP 2014500723-A/14311: Polycomb-Associated Non-Coding RNAs.
JD141475 - Sequence 122499 from Patent EP1572962.
JD131999 - Sequence 113023 from Patent EP1572962.
JD251529 - Sequence 232553 from Patent EP1572962.
JD039548 - Sequence 20572 from Patent EP1572962.
JD056528 - Sequence 37552 from Patent EP1572962.
LF358113 - JP 2014500723-A/165616: Polycomb-Associated Non-Coding RNAs.
AF224759 - Homo sapiens adenocarcinoma antigen ART1/P17 mRNA, complete cds.
BC045638 - Homo sapiens cDNA clone IMAGE:5299605, containing frame-shift errors.
BC074000 - Homo sapiens suppressor of Ty 7 (S. cerevisiae)-like, mRNA (cDNA clone MGC:90306 IMAGE:6501232), complete cds.
AK000329 - Homo sapiens cDNA FLJ20322 fis, clone HEP09455, highly similar to AB018307 Homo sapiens mRNA for KIAA0764 protein.
AF197954 - Homo sapiens adenocarcinoma antigen ART1 mRNA, complete cds.
AK304889 - Homo sapiens cDNA FLJ57460 complete cds, highly similar to STAGA complex 65 subunit gamma.
JD236451 - Sequence 217475 from Patent EP1572962.
JD116056 - Sequence 97080 from Patent EP1572962.
AK000616 - Homo sapiens cDNA FLJ20609 fis, clone KAT05969, highly similar to AB018307 Homo sapiens mRNA for KIAA0764 protein.
JD449122 - Sequence 430146 from Patent EP1572962.
CR456983 - Homo sapiens full open reading frame cDNA clone RZPDo834D025D for gene STAF65(gamma), SPTF-associated factor 65 gamma; complete cds, incl. stopcodon.
AB383982 - Synthetic construct DNA, clone: pF1KSDA0764, Homo sapiens SUPT7L gene for STAGA complex 65 subunit gamma, complete cds, without stop codon, in Flexi system.
LF358114 - JP 2014500723-A/165617: Polycomb-Associated Non-Coding RNAs.
LF358117 - JP 2014500723-A/165620: Polycomb-Associated Non-Coding RNAs.
JD494708 - Sequence 475732 from Patent EP1572962.
JD107376 - Sequence 88400 from Patent EP1572962.
JD521808 - Sequence 502832 from Patent EP1572962.
LF385487 - JP 2014500723-A/192990: Polycomb-Associated Non-Coding RNAs.
MA621085 - JP 2018138019-A/193011: Polycomb-Associated Non-Coding RNAs.
MA621064 - JP 2018138019-A/192990: Polycomb-Associated Non-Coding RNAs.
MA442385 - JP 2018138019-A/14311: Polycomb-Associated Non-Coding RNAs.
MA593690 - JP 2018138019-A/165616: Polycomb-Associated Non-Coding RNAs.
MA593691 - JP 2018138019-A/165617: Polycomb-Associated Non-Coding RNAs.
MA593694 - JP 2018138019-A/165620: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O94864 (Reactome details) participates in the following event(s):

R-HSA-3301237 KAT2 complexes acetylate histone H3
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA0764, NM_014860, NP_055675, O94864, Q6IB21, Q9H2T6, ST65G_HUMAN
UCSC ID: uc002rli.1
RefSeq Accession: NM_014860
Protein: O94864 (aka ST65G_HUMAN)
CCDS: CCDS42667.1, CCDS62885.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014860.1
exon count: 6CDS single in 3' UTR: no RNA size: 4261
ORF size: 1245CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 2655.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.