Human Gene PI4KB (uc001exu.3) Description and Page Index
  Description: Homo sapiens phosphatidylinositol 4-kinase, catalytic, beta (PI4KB), transcript variant 3, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:151,264,273-151,300,191 Size: 35,919 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:151,265,328-151,288,957 Size: 23,630 Coding Exon Count: 10 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:151,264,273-151,300,191)mRNA (may differ from genome)Protein (801 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
ReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PI4KB
CDC HuGE Published Literature: PI4KB
Positive Disease Associations: Magnesium
Related Studies:
  1. Magnesium
    , , . [PubMed 0]
  2. Magnesium
    , , . [PubMed 0]
  3. Magnesium
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.92 RPKM in Nerve - Tibial
Total median expression: 962.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -206.30473-0.436 Picture PostScript Text
3' UTR -413.171055-0.392 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00454 - Phosphatidylinositol 3- and 4-kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9UBF8-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Descriptions from all associated GenBank mRNAs
  AB005910 - Homo sapiens mRNA for phosphatidylinositol 4-kinase, complete cds.
DI487055 - KR 1020100056450-A/151: DSRNA FOR TREATING VIRAL INFECTION.
JD114171 - Sequence 95195 from Patent EP1572962.
AL832188 - Homo sapiens mRNA; cDNA DKFZp686O1820 (from clone DKFZp686O1820).
BC000029 - Homo sapiens phosphatidylinositol 4-kinase, catalytic, beta, mRNA (cDNA clone MGC:1921 IMAGE:3508885), complete cds.
AK054691 - Homo sapiens cDNA FLJ30129 fis, clone BRACE1000131.
AJ011121 - Homo sapiens mRNA for phosphatidylinositol 4-kinase (NPIK-A).
AJ011122 - Homo sapiens mRNA for phosphatidylinositol 4-kinase (NPIK-B).
AJ011123 - Homo sapiens mRNA for phosphatidylinositol 4-kinase (NPIK-C).
BC040300 - Homo sapiens phosphatidylinositol 4-kinase, catalytic, beta, mRNA (cDNA clone MGC:42391 IMAGE:4821417), complete cds.
JD420600 - Sequence 401624 from Patent EP1572962.
JD519242 - Sequence 500266 from Patent EP1572962.
JD347385 - Sequence 328409 from Patent EP1572962.
JD109251 - Sequence 90275 from Patent EP1572962.
DI487091 - KR 1020100056450-A/187: DSRNA FOR TREATING VIRAL INFECTION.
JD098293 - Sequence 79317 from Patent EP1572962.
JD489505 - Sequence 470529 from Patent EP1572962.
JD217566 - Sequence 198590 from Patent EP1572962.
JD108370 - Sequence 89394 from Patent EP1572962.
JD159179 - Sequence 140203 from Patent EP1572962.
DI487042 - KR 1020100056450-A/138: DSRNA FOR TREATING VIRAL INFECTION.
JD469347 - Sequence 450371 from Patent EP1572962.
JD426209 - Sequence 407233 from Patent EP1572962.
U81802 - Human PtdIns 4-kinase (PI4Kb) mRNA, complete cds.
JD426239 - Sequence 407263 from Patent EP1572962.
JD324828 - Sequence 305852 from Patent EP1572962.
JD151226 - Sequence 132250 from Patent EP1572962.
JD294613 - Sequence 275637 from Patent EP1572962.
JD200886 - Sequence 181910 from Patent EP1572962.
JD204978 - Sequence 186002 from Patent EP1572962.
JD444851 - Sequence 425875 from Patent EP1572962.
AK294606 - Homo sapiens cDNA FLJ57971 complete cds, highly similar to Phosphatidylinositol 4-kinase beta (EC 2.7.1.67).
JD328275 - Sequence 309299 from Patent EP1572962.
JD343850 - Sequence 324874 from Patent EP1572962.
JD055549 - Sequence 36573 from Patent EP1572962.
KJ905268 - Synthetic construct Homo sapiens clone ccsbBroadEn_14765 PI4KB gene, encodes complete protein.
AB590088 - Synthetic construct DNA, clone: pFN21AB5785, Homo sapiens PI4KB gene for phosphatidylinositol 4-kinase, catalytic, beta, without stop codon, in Flexi system.
DI487085 - KR 1020100056450-A/181: DSRNA FOR TREATING VIRAL INFECTION.
DI487058 - KR 1020100056450-A/154: DSRNA FOR TREATING VIRAL INFECTION.
DI487023 - KR 1020100056450-A/119: DSRNA FOR TREATING VIRAL INFECTION.
AK311292 - Homo sapiens cDNA, FLJ18334.
DI487043 - KR 1020100056450-A/139: DSRNA FOR TREATING VIRAL INFECTION.
DI487087 - KR 1020100056450-A/183: DSRNA FOR TREATING VIRAL INFECTION.
DI487025 - KR 1020100056450-A/121: DSRNA FOR TREATING VIRAL INFECTION.
CU691848 - Synthetic construct Homo sapiens gateway clone IMAGE:100020097 5' read PI4KB mRNA.
DI487066 - KR 1020100056450-A/162: DSRNA FOR TREATING VIRAL INFECTION.
DI487030 - KR 1020100056450-A/126: DSRNA FOR TREATING VIRAL INFECTION.
DI487076 - KR 1020100056450-A/172: DSRNA FOR TREATING VIRAL INFECTION.
DI487099 - KR 1020100056450-A/195: DSRNA FOR TREATING VIRAL INFECTION.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00562 - Inositol phosphate metabolism
hsa01100 - Metabolic pathways
hsa04070 - Phosphatidylinositol signaling system

BioCyc Knowledge Library
PWY-6351 - D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY-6352 - 3-phosphoinositide biosynthesis
PWY3DJ-219 - PIP metabolism

Reactome (by CSHL, EBI, and GO)

Protein Q9UBF8 (Reactome details) participates in the following event(s):

R-HSA-1676152 PI4KB binds to ARF1/3:GTP at the Golgi membrane
R-HSA-1675883 PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001198774, NP_001185704, PIK4CB, Q9UBF8-2
UCSC ID: uc001exu.3
RefSeq Accession: NM_001198774
Protein: Q9UBF8-2, splice isoform of Q9UBF8 CCDS: CCDS993.1, CCDS55638.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001198774.1
exon count: 11CDS single in 3' UTR: no RNA size: 3934
ORF size: 2406CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 4931.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.