Human Gene BEX4 (uc004ejw.4) Description and Page Index
  Description: Homo sapiens brain expressed, X-linked 4 (BEX4), transcript variant 1, mRNA.
RefSeq Summary (NM_001127688): This gene is a member of the brain expressed X-linked gene family. The proteins encoded by some of the other members of this family act as transcription elongation factors which allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chrX:102,470,020-102,472,128 Size: 2,109 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chrX:102,471,082-102,471,444 Size: 363 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:102,470,020-102,472,128)mRNA (may differ from genome)Protein (120 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein BEX4; AltName: Full=BEX1-like protein 1; AltName: Full=Brain-expressed X-linked protein 4; AltName: Full=Nerve growth factor receptor-associated protein 3;
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
PTM: Ubiquitinated. Degraded by the proteasome (By similarity).
SIMILARITY: Belongs to the BEX family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 193.61 RPKM in Brain - Hypothalamus
Total median expression: 3063.45 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.50152-0.418 Picture PostScript Text
3' UTR -148.52684-0.217 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007623 - BEX
IPR021156 - TF_A-like/BEX-like

Pfam Domains:
PF04538 - Brain expressed X-linked like family

ModBase Predicted Comparative 3D Structure on Q9NWD9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042826 histone deacetylase binding
GO:0043014 alpha-tubulin binding

Biological Process:
GO:0007059 chromosome segregation
GO:0030334 regulation of cell migration
GO:0042127 regulation of cell proliferation
GO:1904428 negative regulation of tubulin deacetylation

Cellular Component:
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

-  Descriptions from all associated GenBank mRNAs
  AK000959 - Homo sapiens cDNA FLJ10097 fis, clone HEMBA1002458, weakly similar to OVARIAN GRANULOSA CELL 13.0 KD PROTEIN HGR74.
AY833563 - Homo sapiens chromosome X brain expressed X-linked 4 (BEX4) mRNA, complete cds.
BC015794 - Homo sapiens brain expressed X-linked-like 1, mRNA (cDNA clone IMAGE:3909303), partial cds.
BC068069 - Homo sapiens brain expressed X-linked-like 1, mRNA (cDNA clone IMAGE:4890235), partial cds.
JD231645 - Sequence 212669 from Patent EP1572962.
LF319885 - JP 2014500723-A/127388: Polycomb-Associated Non-Coding RNAs.
LF205386 - JP 2014500723-A/12889: Polycomb-Associated Non-Coding RNAs.
JD388430 - Sequence 369454 from Patent EP1572962.
BC148484 - Synthetic construct Homo sapiens clone IMAGE:100015430, MGC:183031 brain expressed, X-linked 4 (BEX4) mRNA, encodes complete protein.
BC156670 - Synthetic construct Homo sapiens clone IMAGE:100062154, MGC:190184 brain expressed, X-linked 4 (BEX4) mRNA, encodes complete protein.
LF319883 - JP 2014500723-A/127386: Polycomb-Associated Non-Coding RNAs.
JD312909 - Sequence 293933 from Patent EP1572962.
JD038389 - Sequence 19413 from Patent EP1572962.
JD281154 - Sequence 262178 from Patent EP1572962.
JD491342 - Sequence 472366 from Patent EP1572962.
JD250406 - Sequence 231430 from Patent EP1572962.
JD386289 - Sequence 367313 from Patent EP1572962.
JD452979 - Sequence 434003 from Patent EP1572962.
JD498735 - Sequence 479759 from Patent EP1572962.
JD525275 - Sequence 506299 from Patent EP1572962.
MA555462 - JP 2018138019-A/127388: Polycomb-Associated Non-Coding RNAs.
MA440963 - JP 2018138019-A/12889: Polycomb-Associated Non-Coding RNAs.
MA555460 - JP 2018138019-A/127386: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BEX4_HUMAN, BEXL1, NADE3, NM_001127688, NP_001121160, Q9NWD9
UCSC ID: uc004ejw.4
RefSeq Accession: NM_001127688
Protein: Q9NWD9 (aka BEX4_HUMAN)
CCDS: CCDS35355.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001127688.2
exon count: 2CDS single in 3' UTR: no RNA size: 1199
ORF size: 363CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 926.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.