Human Gene FIS1 (uc003uyj.4) Description and Page Index
Description: Homo sapiens fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) (FIS1), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_016068): The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.347142.1, SRR1163655.172599.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr7:100,882,893-100,888,371 Size: 5,479 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr7:100,883,087-100,888,285 Size: 5,199 Coding Exon Count: 5
ID:FIS1_HUMAN DESCRIPTION: RecName: Full=Mitochondrial fission 1 protein; AltName: Full=FIS1 homolog; Short=hFis1; AltName: Full=Tetratricopeptide repeat protein 11; Short=TPR repeat protein 11; FUNCTION: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. SUBUNIT: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5. Interacts with MID51. INTERACTION: P51572:BCAP31; NbExp=8; IntAct=EBI-3385283, EBI-77683; SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. DOMAIN: The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L. PTM: Ubiquitinated by MARCH5. SIMILARITY: Belongs to the FIS1 family. SIMILARITY: Contains 1 TPR repeat.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FIS1 CDC HuGE Published Literature: FIS1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y3D6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000266 mitochondrial fission GO:0000422 mitophagy GO:0001836 release of cytochrome c from mitochondria GO:0006626 protein targeting to mitochondrion GO:0006915 apoptotic process GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0008053 mitochondrial fusion GO:0010821 regulation of mitochondrion organization GO:0014850 response to muscle activity GO:0016559 peroxisome fission GO:0031667 response to nutrient levels GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration GO:0035584 calcium-mediated signaling using intracellular calcium source GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043653 mitochondrial fragmentation involved in apoptotic process GO:0051260 protein homooligomerization GO:0051561 positive regulation of mitochondrial calcium ion concentration GO:0070584 mitochondrion morphogenesis GO:0071333 cellular response to glucose stimulus GO:0071396 cellular response to lipid GO:0090141 positive regulation of mitochondrial fission GO:0090314 positive regulation of protein targeting to membrane GO:0097237 cellular response to toxic substance GO:1901653 cellular response to peptide GO:1902617 response to fluoride GO:1904579 cellular response to thapsigargin GO:1905395 response to flavonoid GO:1990910 response to hypobaric hypoxia GO:2001244 positive regulation of intrinsic apoptotic signaling pathway