Human Gene ARL6IP1 (uc002dfl.1) Description and Page Index
Description: Homo sapiens ADP-ribosylation factor-like 6 interacting protein 1 (ARL6IP1), mRNA. RefSeq Summary (NM_015161): This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr16:18,802,991-18,812,857 Size: 9,867 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr16:18,804,574-18,812,788 Size: 8,215 Coding Exon Count: 6
ID:AR6P1_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor-like protein 6-interacting protein 1; Short=ARL-6-interacting protein 1; Short=Aip-1; FUNCTION: May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. SUBUNIT: Interacts with ARL6 (By similarity). INTERACTION: P51116:FXR2; NbExp=3; IntAct=EBI-714543, EBI-740459; SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein. Note=Predominantly localized to intracytoplasmic membranes. TISSUE SPECIFICITY: Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart. DEVELOPMENTAL STAGE: Down-regulated during myeloid differentiation. SIMILARITY: Belongs to the ARL6ip family. SEQUENCE CAUTION: Sequence=BAA06683.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15041
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002038 positive regulation of L-glutamate transport GO:0006613 cotranslational protein targeting to membrane GO:0006915 apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0071787 endoplasmic reticulum tubular network assembly GO:1990809 endoplasmic reticulum tubular network membrane organization