Human Gene PEA15 (uc001fvk.3) Description and Page Index
Description: Homo sapiens phosphoprotein enriched in astrocytes 15 (PEA15), mRNA. RefSeq Summary (NM_003768): This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr1:160,175,125-160,185,162 Size: 10,038 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr1:160,181,335-160,183,276 Size: 1,942 Coding Exon Count: 3
ID:PEA15_HUMAN DESCRIPTION: RecName: Full=Astrocytic phosphoprotein PEA-15; AltName: Full=15 kDa phosphoprotein enriched in astrocytes; AltName: Full=Phosphoprotein enriched in diabetes; Short=PED; FUNCTION: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. SUBUNIT: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD. SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules. TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. PTM: Phosphorylated by protein kinase C and calcium-calmodulin- dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. SIMILARITY: Contains 1 DED (death effector) domain.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PEA15 CDC HuGE Published Literature: PEA15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15121
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000077 DNA damage checkpoint GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0006915 apoptotic process GO:0008643 carbohydrate transport GO:0042981 regulation of apoptotic process GO:0043278 response to morphine GO:0046325 negative regulation of glucose import GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors