Human Gene PEA15 (uc001fvk.3) Description and Page Index
  Description: Homo sapiens phosphoprotein enriched in astrocytes 15 (PEA15), mRNA.
RefSeq Summary (NM_003768): This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Transcript (Including UTRs)
   Position: hg19 chr1:160,175,125-160,185,162 Size: 10,038 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:160,181,335-160,183,276 Size: 1,942 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:160,175,125-160,185,162)mRNA (may differ from genome)Protein (130 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Astrocytic phosphoprotein PEA-15; AltName: Full=15 kDa phosphoprotein enriched in astrocytes; AltName: Full=Phosphoprotein enriched in diabetes; Short=PED;
FUNCTION: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
SUBUNIT: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules.
TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
PTM: Phosphorylated by protein kinase C and calcium-calmodulin- dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
SIMILARITY: Contains 1 DED (death effector) domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PEA15
CDC HuGE Published Literature: PEA15

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 844.34 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 8043.47 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.10190-0.527 Picture PostScript Text
3' UTR -675.951886-0.358 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011029 - DEATH-like
IPR001875 - DED

Pfam Domains:
PF01335 - Death effector domain

SCOP Domains:
47986 - DEATH domain

ModBase Predicted Comparative 3D Structure on Q15121
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000077 DNA damage checkpoint
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0006915 apoptotic process
GO:0008643 carbohydrate transport
GO:0042981 regulation of apoptotic process
GO:0043278 response to morphine
GO:0046325 negative regulation of glucose import
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005875 microtubule associated complex

-  Descriptions from all associated GenBank mRNAs
  LF205468 - JP 2014500723-A/12971: Polycomb-Associated Non-Coding RNAs.
BC022554 - Homo sapiens phosphoprotein enriched in astrocytes 15, mRNA (cDNA clone MGC:26842 IMAGE:4820225), complete cds.
AK311762 - Homo sapiens cDNA, FLJ92023, Homo sapiens phosphoprotein enriched in astrocytes 15 (PEA15),mRNA.
AK095879 - Homo sapiens cDNA FLJ38560 fis, clone HCHON2003642, highly similar to Astrocytic phosphoprotein PEA-15.
X86809 - H.sapiens mRNA for major astrocytic phosphoprotein PEA-15.
BC002426 - Homo sapiens phosphoprotein enriched in astrocytes 15, mRNA (cDNA clone MGC:1685 IMAGE:3346270), complete cds.
LF320809 - JP 2014500723-A/128312: Polycomb-Associated Non-Coding RNAs.
Y13736 - Homo sapiens mRNA for PED phosphoprotein.
JD057456 - Sequence 38480 from Patent EP1572962.
AB528321 - Synthetic construct DNA, clone: pF1KB5425, Homo sapiens PEA15 gene for phosphoprotein enriched in astrocytes 15, without stop codon, in Flexi system.
DQ891821 - Synthetic construct clone IMAGE:100004451; FLH180277.01X; RZPDo839A06134D phosphoprotein enriched in astrocytes 15 (PEA15) gene, encodes complete protein.
DQ891824 - Synthetic construct Homo sapiens clone IMAGE:100004454; FLH263509.01X; RZPDo839A09134D phosphoprotein enriched in astrocytes 15 (PEA15) gene, encodes complete protein.
DQ895008 - Synthetic construct Homo sapiens clone IMAGE:100009468; FLH180273.01L; RZPDo839A06133D phosphoprotein enriched in astrocytes 15 (PEA15) gene, encodes complete protein.
KJ892595 - Synthetic construct Homo sapiens clone ccsbBroadEn_01989 PEA15 gene, encodes complete protein.
KJ897890 - Synthetic construct Homo sapiens clone ccsbBroadEn_07284 PEA15 gene, encodes complete protein.
BT007252 - Homo sapiens phosphoprotein enriched in astrocytes 15 mRNA, complete cds.
CR541733 - Homo sapiens full open reading frame cDNA clone RZPDo834C1229D for gene PEA15, phosphoprotein enriched in astrocytes 15; complete cds, incl. stopcodon.
LF320799 - JP 2014500723-A/128302: Polycomb-Associated Non-Coding RNAs.
LF320797 - JP 2014500723-A/128300: Polycomb-Associated Non-Coding RNAs.
JD023151 - Sequence 4175 from Patent EP1572962.
JD019448 - Sequence 472 from Patent EP1572962.
JD030536 - Sequence 11560 from Patent EP1572962.
LF320794 - JP 2014500723-A/128297: Polycomb-Associated Non-Coding RNAs.
JD158482 - Sequence 139506 from Patent EP1572962.
JD362205 - Sequence 343229 from Patent EP1572962.
JD073963 - Sequence 54987 from Patent EP1572962.
JD282260 - Sequence 263284 from Patent EP1572962.
JD538037 - Sequence 519061 from Patent EP1572962.
JD268749 - Sequence 249773 from Patent EP1572962.
JD185935 - Sequence 166959 from Patent EP1572962.
LF320793 - JP 2014500723-A/128296: Polycomb-Associated Non-Coding RNAs.
JD438505 - Sequence 419529 from Patent EP1572962.
JD441370 - Sequence 422394 from Patent EP1572962.
LF320792 - JP 2014500723-A/128295: Polycomb-Associated Non-Coding RNAs.
JD101399 - Sequence 82423 from Patent EP1572962.
LF320791 - JP 2014500723-A/128294: Polycomb-Associated Non-Coding RNAs.
L37385 - Homo sapiens homolog of mouse MAT-1 oncogene mRNA, complete cds.
JD545871 - Sequence 526895 from Patent EP1572962.
JD239491 - Sequence 220515 from Patent EP1572962.
JD356114 - Sequence 337138 from Patent EP1572962.
JD482262 - Sequence 463286 from Patent EP1572962.
JD445628 - Sequence 426652 from Patent EP1572962.
JD130441 - Sequence 111465 from Patent EP1572962.
JD367022 - Sequence 348046 from Patent EP1572962.
BC010469 - Homo sapiens phosphoprotein enriched in astrocytes 15, mRNA (cDNA clone MGC:17004 IMAGE:4157570), complete cds.
JD058828 - Sequence 39852 from Patent EP1572962.
JD123056 - Sequence 104080 from Patent EP1572962.
DQ579760 - Homo sapiens piRNA piR-47872, complete sequence.
KJ901899 - Synthetic construct Homo sapiens clone ccsbBroadEn_11293 PEA15 gene, encodes complete protein.
JD104036 - Sequence 85060 from Patent EP1572962.
JD495079 - Sequence 476103 from Patent EP1572962.
JD479961 - Sequence 460985 from Patent EP1572962.
JD157365 - Sequence 138389 from Patent EP1572962.
JD038865 - Sequence 19889 from Patent EP1572962.
JD339218 - Sequence 320242 from Patent EP1572962.
JD362628 - Sequence 343652 from Patent EP1572962.
JD136621 - Sequence 117645 from Patent EP1572962.
JD213751 - Sequence 194775 from Patent EP1572962.
JD183927 - Sequence 164951 from Patent EP1572962.
JD293611 - Sequence 274635 from Patent EP1572962.
JD231153 - Sequence 212177 from Patent EP1572962.
MA441045 - JP 2018138019-A/12971: Polycomb-Associated Non-Coding RNAs.
MA556386 - JP 2018138019-A/128312: Polycomb-Associated Non-Coding RNAs.
MA556376 - JP 2018138019-A/128302: Polycomb-Associated Non-Coding RNAs.
MA556374 - JP 2018138019-A/128300: Polycomb-Associated Non-Coding RNAs.
MA556371 - JP 2018138019-A/128297: Polycomb-Associated Non-Coding RNAs.
MA556370 - JP 2018138019-A/128296: Polycomb-Associated Non-Coding RNAs.
MA556369 - JP 2018138019-A/128295: Polycomb-Associated Non-Coding RNAs.
MA556368 - JP 2018138019-A/128294: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q15121 (Reactome details) participates in the following event(s):

R-HSA-5675206 PEA15 binds MAPK monomers and dimers
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_003768, NP_003759, O00511, PEA15_HUMAN, Q15121
UCSC ID: uc001fvk.3
RefSeq Accession: NM_003768
Protein: Q15121 (aka PEA15_HUMAN)
CCDS: CCDS1199.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003768.3
exon count: 4CDS single in 3' UTR: no RNA size: 2474
ORF size: 393CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 755.00frame shift in genome: no % Coverage: 99.80
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.