Human Gene C11orf87 (uc010rwb.2) Description and Page Index
  Description: Homo sapiens chromosome 11 open reading frame 87 (C11orf87), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:109,292,846-109,299,893 Size: 7,048 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr11:109,294,360-109,294,953 Size: 594 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:109,292,846-109,299,893)mRNA (may differ from genome)Protein (197 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Uncharacterized protein C11orf87; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): C11orf87
CDC HuGE Published Literature: C11orf87
Positive Disease Associations: Blood Pressure , Body Weight , C-Reactive Protein , Diabetic Nephropathies , Stroke
Related Studies:
  1. Blood Pressure
    Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics. [PubMed 17903302]
    These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
  2. Body Weight
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  3. C-Reactive Protein
    Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics. [PubMed 17903293]
    The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.49 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 60.31 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -192.40403-0.477 Picture PostScript Text
3' UTR -1305.584940-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q6NUJ2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  AK303693 - Homo sapiens cDNA FLJ55424 complete cds.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JD211258 - Sequence 192282 from Patent EP1572962.
BC068577 - Homo sapiens chromosome 11 open reading frame 87, mRNA (cDNA clone MGC:87557 IMAGE:4818568), complete cds.
JD141153 - Sequence 122177 from Patent EP1572962.
BC035798 - Homo sapiens chromosome 11 open reading frame 87, mRNA (cDNA clone MGC:46342 IMAGE:5735100), complete cds.
JD104083 - Sequence 85107 from Patent EP1572962.
JD545954 - Sequence 526978 from Patent EP1572962.
JD506116 - Sequence 487140 from Patent EP1572962.
JD233001 - Sequence 214025 from Patent EP1572962.
JD077044 - Sequence 58068 from Patent EP1572962.
KJ900724 - Synthetic construct Homo sapiens clone ccsbBroadEn_10118 C11orf87 gene, encodes complete protein.
AB096240 - Homo sapiens LOH11CR1A gene, loss of heterozygosity, 11, chromosomal region 1 gene A product.
JD392143 - Sequence 373167 from Patent EP1572962.
JD126144 - Sequence 107168 from Patent EP1572962.
JD521570 - Sequence 502594 from Patent EP1572962.
JD300082 - Sequence 281106 from Patent EP1572962.
JD133540 - Sequence 114564 from Patent EP1572962.
JD322610 - Sequence 303634 from Patent EP1572962.
JD429301 - Sequence 410325 from Patent EP1572962.
JD306614 - Sequence 287638 from Patent EP1572962.
JD127261 - Sequence 108285 from Patent EP1572962.
JD328187 - Sequence 309211 from Patent EP1572962.
JD067650 - Sequence 48674 from Patent EP1572962.
JD564249 - Sequence 545273 from Patent EP1572962.
JD373599 - Sequence 354623 from Patent EP1572962.
JD044587 - Sequence 25611 from Patent EP1572962.
JD353680 - Sequence 334704 from Patent EP1572962.
JD216062 - Sequence 197086 from Patent EP1572962.
JD155323 - Sequence 136347 from Patent EP1572962.
JD279460 - Sequence 260484 from Patent EP1572962.
JD303353 - Sequence 284377 from Patent EP1572962.
JD063301 - Sequence 44325 from Patent EP1572962.
AK091086 - Homo sapiens cDNA FLJ33767 fis, clone BRHIP1000108.

-  Other Names for This Gene
  Alternate Gene Symbols: B4E169, CK087_HUMAN, NM_207645, NP_997528, Q6NUJ2
UCSC ID: uc010rwb.2
RefSeq Accession: NM_207645
Protein: Q6NUJ2 (aka CK087_HUMAN)
CCDS: CCDS31672.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_207645.3
exon count: 2CDS single in 3' UTR: no RNA size: 5937
ORF size: 594CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1288.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.