Human Gene ZDHHC22 (uc010asp.3) Description and Page Index
  Description: Homo sapiens zinc finger, DHHC-type containing 22 (ZDHHC22), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:77,597,613-77,608,134 Size: 10,522 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr14:77,600,026-77,606,081 Size: 6,056 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:77,597,613-77,608,134)mRNA (may differ from genome)Protein (263 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative palmitoyltransferase ZDHHC22; EC=2.3.1.-; AltName: Full=Zinc finger DHHC domain-containing protein 22; Short=DHHC-22;
CATALYTIC ACTIVITY: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
DOMAIN: The DHHC domain is required for palmitoyltransferase activity (By similarity).
SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
SIMILARITY: Contains 1 DHHC-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.34 RPKM in Brain - Cortex
Total median expression: 152.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.50203-0.401 Picture PostScript Text
3' UTR -930.252413-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000731 - SSD
IPR001594 - Znf_DHHC_palmitoyltrfase

Pfam Domains:
PF01529 - DHHC palmitoyltransferase

ModBase Predicted Comparative 3D Structure on Q8N966
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0019706 protein-cysteine S-palmitoyltransferase activity

Biological Process:
GO:0018345 protein palmitoylation
GO:0072659 protein localization to plasma membrane

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC035881 - Homo sapiens zinc finger, DHHC-type containing 22, mRNA (cDNA clone IMAGE:4939155).
AK095612 - Homo sapiens cDNA FLJ38293 fis, clone FCBBF3009526.
JD544289 - Sequence 525313 from Patent EP1572962.
JD409579 - Sequence 390603 from Patent EP1572962.
JD105143 - Sequence 86167 from Patent EP1572962.
JD383620 - Sequence 364644 from Patent EP1572962.
JD286449 - Sequence 267473 from Patent EP1572962.
JD402957 - Sequence 383981 from Patent EP1572962.
JD295765 - Sequence 276789 from Patent EP1572962.
JD323629 - Sequence 304653 from Patent EP1572962.
JD108947 - Sequence 89971 from Patent EP1572962.
JD309221 - Sequence 290245 from Patent EP1572962.
JD448942 - Sequence 429966 from Patent EP1572962.
JD153883 - Sequence 134907 from Patent EP1572962.
JD500234 - Sequence 481258 from Patent EP1572962.
JD113513 - Sequence 94537 from Patent EP1572962.
JD478731 - Sequence 459755 from Patent EP1572962.
JD184077 - Sequence 165101 from Patent EP1572962.
JD489715 - Sequence 470739 from Patent EP1572962.
JD139636 - Sequence 120660 from Patent EP1572962.
JD338804 - Sequence 319828 from Patent EP1572962.
JD129815 - Sequence 110839 from Patent EP1572962.
JD125073 - Sequence 106097 from Patent EP1572962.
BC117676 - Homo sapiens zinc finger, DHHC-type containing 22, mRNA (cDNA clone MGC:134868 IMAGE:40069732), complete cds.
JD546162 - Sequence 527186 from Patent EP1572962.
JD217869 - Sequence 198893 from Patent EP1572962.
JD074401 - Sequence 55425 from Patent EP1572962.
JD402175 - Sequence 383199 from Patent EP1572962.
JD113560 - Sequence 94584 from Patent EP1572962.
JD385780 - Sequence 366804 from Patent EP1572962.
JD215548 - Sequence 196572 from Patent EP1572962.
JD045349 - Sequence 26373 from Patent EP1572962.
JD039104 - Sequence 20128 from Patent EP1572962.
JD286386 - Sequence 267410 from Patent EP1572962.
JD503110 - Sequence 484134 from Patent EP1572962.
JD273502 - Sequence 254526 from Patent EP1572962.
JD401351 - Sequence 382375 from Patent EP1572962.
JD104378 - Sequence 85402 from Patent EP1572962.
JD383417 - Sequence 364441 from Patent EP1572962.
JD206453 - Sequence 187477 from Patent EP1572962.
JD330096 - Sequence 311120 from Patent EP1572962.
JD466709 - Sequence 447733 from Patent EP1572962.
AK294840 - Homo sapiens cDNA FLJ56872 complete cds, highly similar to Rattus norvegicus zinc finger, DHHC-type containing 22 (Zdhhc22), mRNA.
JD251732 - Sequence 232756 from Patent EP1572962.
JD206871 - Sequence 187895 from Patent EP1572962.
JD419702 - Sequence 400726 from Patent EP1572962.
JD241984 - Sequence 223008 from Patent EP1572962.
JD086869 - Sequence 67893 from Patent EP1572962.
JD119618 - Sequence 100642 from Patent EP1572962.
KJ895966 - Synthetic construct Homo sapiens clone ccsbBroadEn_05360 ZDHHC22 gene, encodes complete protein.
JD351503 - Sequence 332527 from Patent EP1572962.
JD395129 - Sequence 376153 from Patent EP1572962.
JD138555 - Sequence 119579 from Patent EP1572962.
JD408437 - Sequence 389461 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NH02, B7Z2L5, C14orf59, NM_174976, NP_777636, Q149P4, Q8N966, ZDH22_HUMAN
UCSC ID: uc010asp.3
RefSeq Accession: NM_174976
Protein: Q8N966 (aka ZDH22_HUMAN)
CCDS: CCDS45140.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_174976.2
exon count: 3CDS single in 3' UTR: no RNA size: 3408
ORF size: 792CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1778.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.