Human Gene KCNIP1 (uc003map.3) Description and Page Index
Description: Homo sapiens Kv channel interacting protein 1 (KCNIP1), transcript variant 3, mRNA. RefSeq Summary (NM_001034838): This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. Transcript (Including UTRs) Position: hg19 chr5:169,780,881-170,163,636 Size: 382,756 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr5:169,780,881-170,162,810 Size: 381,930 Coding Exon Count: 8
Multiple Sclerosis Sergio E Baranzini et al. Human molecular genetics 2009, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis., Human molecular genetics.
normalized brain volume, multiple sclerosis Baranzini ,et al. 2008, Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis, Human molecular genetics 2009 18- 4 : 767-78.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3YAD3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.