Human Gene CREG2 (uc002tba.2) Description and Page Index
  Description: Homo sapiens cellular repressor of E1A-stimulated genes 2 (CREG2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:101,964,816-102,003,965 Size: 39,150 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:101,967,385-102,003,919 Size: 36,535 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:101,964,816-102,003,965)mRNA (may differ from genome)Protein (290 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CREG2_HUMAN
DESCRIPTION: RecName: Full=Protein CREG2; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum.
PTM: It is not sure whether N-glycosylation is on Asn-165 and/or Asn-166.
SIMILARITY: Belongs to the CREG family.
SEQUENCE CAUTION: Sequence=BAC04464.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CREG2
CDC HuGE Published Literature: CREG2
Positive Disease Associations: Glucose
Related Studies:
  1. Glucose
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.57 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 88.79 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.5046-0.489 Picture PostScript Text
3' UTR -707.382569-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014631 - CREG
IPR012349 - Split_barrel_FMN-bd
IPR009002 - Split_barrel_FMN-bd-related

Pfam Domains:
PF13883 - Pyridoxamine 5'-phosphate oxidase

SCOP Domains:
50475 - FMN-binding split barrel

ModBase Predicted Comparative 3D Structure on Q8IUH2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0048037 cofactor binding

Cellular Component:
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  AB046109 - Homo sapiens hCREG2 mRNA for CREG2, complete cds.
BC032949 - Homo sapiens cellular repressor of E1A-stimulated genes 2, mRNA (cDNA clone MGC:33323 IMAGE:4814957), complete cds.
BC047514 - Homo sapiens cellular repressor of E1A-stimulated genes 2, mRNA (cDNA clone MGC:48471 IMAGE:5276849), complete cds.
AK094970 - Homo sapiens cDNA FLJ37651 fis, clone BRHIP2009617, weakly similar to Homo sapiens cellular repressor of E1A-stimulated genes CREG mRNA.
KJ900412 - Synthetic construct Homo sapiens clone ccsbBroadEn_09806 CREG2 gene, encodes complete protein.
JD149956 - Sequence 130980 from Patent EP1572962.
JD448996 - Sequence 430020 from Patent EP1572962.
JD361001 - Sequence 342025 from Patent EP1572962.
JD444749 - Sequence 425773 from Patent EP1572962.
JD284902 - Sequence 265926 from Patent EP1572962.
JD286378 - Sequence 267402 from Patent EP1572962.
JD510762 - Sequence 491786 from Patent EP1572962.
JD440250 - Sequence 421274 from Patent EP1572962.
JD265681 - Sequence 246705 from Patent EP1572962.
JD529039 - Sequence 510063 from Patent EP1572962.
JD328826 - Sequence 309850 from Patent EP1572962.
JD386176 - Sequence 367200 from Patent EP1572962.
JD310064 - Sequence 291088 from Patent EP1572962.
JD038607 - Sequence 19631 from Patent EP1572962.
JD528000 - Sequence 509024 from Patent EP1572962.
JD068317 - Sequence 49341 from Patent EP1572962.
JD164724 - Sequence 145748 from Patent EP1572962.
JD268852 - Sequence 249876 from Patent EP1572962.
JD290038 - Sequence 271062 from Patent EP1572962.
JD073289 - Sequence 54313 from Patent EP1572962.
JD242256 - Sequence 223280 from Patent EP1572962.
JD495379 - Sequence 476403 from Patent EP1572962.
JD066405 - Sequence 47429 from Patent EP1572962.
JD376430 - Sequence 357454 from Patent EP1572962.
JD507864 - Sequence 488888 from Patent EP1572962.
JD309787 - Sequence 290811 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CREG2_HUMAN, NM_153836, NP_722578, Q86X03, Q8IUH2, Q8N540, Q8N9E3
UCSC ID: uc002tba.2
RefSeq Accession: NM_153836
Protein: Q8IUH2 (aka CREG2_HUMAN)
CCDS: CCDS2052.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_153836.3
exon count: 4CDS single in 3' UTR: no RNA size: 3488
ORF size: 873CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1946.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.