Human Gene SLC39A12 (uc001ipo.2) Description and Page Index
Description: Homo sapiens solute carrier family 39 (zinc transporter), member 12 (SLC39A12), transcript variant 1, mRNA. RefSeq Summary (NM_001145195): Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]. Transcript (Including UTRs) Position: hg19 chr10:18,240,768-18,332,221 Size: 91,454 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr10:18,242,206-18,331,762 Size: 89,557 Coding Exon Count: 12
ID:S39AC_HUMAN DESCRIPTION: RecName: Full=Zinc transporter ZIP12; AltName: Full=LIV-1 subfamily of ZIP zinc transporter 8; Short=LZT-Hs8; AltName: Full=Solute carrier family 39 member 12; AltName: Full=Zrt- and Irt-like protein 12; Short=ZIP-12; FUNCTION: Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in brain and eye. SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q504Y0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.