Human Gene ACBD7 (uc001inv.3) Description and Page Index
  Description: Homo sapiens acyl-CoA binding domain containing 7 (ACBD7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:15,117,474-15,130,775 Size: 13,302 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr10:15,120,529-15,130,727 Size: 10,199 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:15,117,474-15,130,775)mRNA (may differ from genome)Protein (88 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ACBD7_HUMAN
DESCRIPTION: RecName: Full=Acyl-CoA-binding domain-containing protein 7;
FUNCTION: Binds medium- and long-chain acyl-CoA esters.
SIMILARITY: Belongs to the ACBD7 family.
SIMILARITY: Contains 1 ACB (acyl-CoA-binding) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.11 RPKM in Brain - Caudate (basal ganglia)
Total median expression: 157.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.7048-0.160 Picture PostScript Text
3' UTR -1145.453055-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000582 - Acyl-CoA-binding_protein
IPR014352 - FERM/acyl-CoA-bd_prot_3-hlx

Pfam Domains:
PF00887 - Acyl CoA binding protein

SCOP Domains:
47027 - Acyl-CoA binding protein
47031 - Second domain of FERM

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3EPY
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q8N6N7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000062 fatty-acyl-CoA binding
GO:0008289 lipid binding


-  Descriptions from all associated GenBank mRNAs
  AK295169 - Homo sapiens cDNA FLJ52263 complete cds, highly similar to Artemis protein (EC 3.1.-.-).
AK095538 - Homo sapiens cDNA FLJ38219 fis, clone FCBBF2001427, highly similar to Acyl-CoA-binding domain-containing protein 7.
JD301098 - Sequence 282122 from Patent EP1572962.
JD388819 - Sequence 369843 from Patent EP1572962.
JD321246 - Sequence 302270 from Patent EP1572962.
JD388818 - Sequence 369842 from Patent EP1572962.
JD457409 - Sequence 438433 from Patent EP1572962.
BC029526 - Homo sapiens acyl-Coenzyme A binding domain containing 7, mRNA (cDNA clone MGC:33893 IMAGE:5301753), complete cds.
JD481443 - Sequence 462467 from Patent EP1572962.
JD413310 - Sequence 394334 from Patent EP1572962.
JD198020 - Sequence 179044 from Patent EP1572962.
JD212642 - Sequence 193666 from Patent EP1572962.
JD249131 - Sequence 230155 from Patent EP1572962.
JD365114 - Sequence 346138 from Patent EP1572962.
JD365115 - Sequence 346139 from Patent EP1572962.
JD534382 - Sequence 515406 from Patent EP1572962.
JD377949 - Sequence 358973 from Patent EP1572962.
JF432125 - Synthetic construct Homo sapiens clone IMAGE:100073264 acyl-Coenzyme A binding domain containing 7 (ACBD7) gene, encodes complete protein.
KJ900754 - Synthetic construct Homo sapiens clone ccsbBroadEn_10148 ACBD7 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N6N7 (Reactome details) participates in the following event(s):

R-HSA-8848246 DBI, ACBD7 bind MCFA-CoA and LCFA-CoA
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A6NCI2, ACBD7_HUMAN, B3KTG8, NM_001039844, NP_001034933, Q8N6N7
UCSC ID: uc001inv.3
RefSeq Accession: NM_001039844
Protein: Q8N6N7 (aka ACBD7_HUMAN)
CCDS: CCDS31153.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001039844.2
exon count: 4CDS single in 3' UTR: no RNA size: 3383
ORF size: 267CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 734.00frame shift in genome: no % Coverage: 99.62
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.