Human Gene RGS7 (uc001hyv.2) Description and Page Index
  Description: Homo sapiens regulator of G-protein signaling 7 (RGS7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:240,938,817-241,520,478 Size: 581,662 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr1:240,939,463-241,519,076 Size: 579,614 Coding Exon Count: 17 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:240,938,817-241,520,478)mRNA (may differ from genome)Protein (487 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB
Wikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RGS7
CDC HuGE Published Literature: RGS7
Positive Disease Associations: Cholesterol , Cholesterol, LDL , Coronary Artery Disease , Glucose , Lipids , Triglycerides
Related Studies:
  1. Cholesterol
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  2. Cholesterol, LDL
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  3. Coronary Artery Disease
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: RGS7
Diseases sorted by gene-association score: uterine benign neoplasm (5), reproductive organ benign neoplasm (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.46 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 159.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -164.80330-0.499 Picture PostScript Text
3' UTR -128.42646-0.199 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF00615 - Regulator of G protein signaling domain
PF00631 - GGL domain

SCOP Domains:
48670 - Transducin (heterotrimeric G protein), gamma chain
46785 - "Winged helix" DNA-binding domain
48097 - Regulator of G-protein signaling, RGS

ModBase Predicted Comparative 3D Structure on P49802-5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK294354 - Homo sapiens cDNA FLJ61685 complete cds, highly similar to Regulator of G-protein signaling 7.
U32439 - Human regulator of G-protein signaling similarity (RGS7) mRNA, partial cds.
AF090116 - Homo sapiens regulator of G-protein signaling 7 (RGS7) mRNA, complete cds.
BC022009 - Homo sapiens regulator of G-protein signaling 7, mRNA (cDNA clone MGC:26289 IMAGE:4823760), complete cds.
AK294234 - Homo sapiens cDNA FLJ55428 complete cds, highly similar to Regulator of G-protein signaling 7.
AF493930 - Homo sapiens regulator of G protein signalling 7 (RGS7) mRNA, complete cds, alternatively spliced.
AF493931 - Homo sapiens regulator of G protein signalling 7 (RGS7) mRNA, complete cds, alternatively spliced.
AY587875 - Homo sapiens regulator of G-protein signaling RGS7 mRNA, complete cds.
AK314862 - Homo sapiens cDNA, FLJ95761.
DQ890794 - Synthetic construct clone IMAGE:100003424; FLH165988.01X; RZPDo839B0786D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
KJ897469 - Synthetic construct Homo sapiens clone ccsbBroadEn_06863 RGS7 gene, encodes complete protein.
DQ893949 - Synthetic construct Homo sapiens clone IMAGE:100008409; FLH165984.01L; RZPDo839B0785D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
DQ893954 - Synthetic construct Homo sapiens clone IMAGE:100008414; FLH263676.01L; RZPDo839C0185D regulator of G-protein signalling 7 (RGS7) gene, encodes complete protein.
AB527513 - Synthetic construct DNA, clone: pF1KB5852, Homo sapiens RGS7 gene for regulator of G-protein signaling 7, without stop codon, in Flexi system.
CU692446 - Synthetic construct Homo sapiens gateway clone IMAGE:100019632 5' read RGS7 mRNA.
AF090117 - Homo sapiens regulator of G-protein signaling 7b (RGS7) mRNA, partial cds.
JD284113 - Sequence 265137 from Patent EP1572962.
JD046440 - Sequence 27464 from Patent EP1572962.
JD424594 - Sequence 405618 from Patent EP1572962.
JD494000 - Sequence 475024 from Patent EP1572962.
JD550672 - Sequence 531696 from Patent EP1572962.
JD149957 - Sequence 130981 from Patent EP1572962.
JD412574 - Sequence 393598 from Patent EP1572962.
JD174627 - Sequence 155651 from Patent EP1572962.
JD171869 - Sequence 152893 from Patent EP1572962.
JD206794 - Sequence 187818 from Patent EP1572962.
DQ139291 - Homo sapiens regulator of G-protein signaling 7 isoform D (RGS7) mRNA, partial cds, alternatively spliced.
DQ139290 - Homo sapiens regulator of G-protein signaling 7 isoform A (RGS7) mRNA, partial cds, alternatively spliced.
JD503342 - Sequence 484366 from Patent EP1572962.
JD266934 - Sequence 247958 from Patent EP1572962.
JD077113 - Sequence 58137 from Patent EP1572962.
JD458299 - Sequence 439323 from Patent EP1572962.
JD523660 - Sequence 504684 from Patent EP1572962.
JD310655 - Sequence 291679 from Patent EP1572962.
JD406384 - Sequence 387408 from Patent EP1572962.
JD442630 - Sequence 423654 from Patent EP1572962.
JD310573 - Sequence 291597 from Patent EP1572962.
JD226496 - Sequence 207520 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P49802 (Reactome details) participates in the following event(s):

R-HSA-8850529 RGS proteins bind GNB5 and CCT/TRiC
R-HSA-8850539 Release of GNB5:RGS dimers from CCT/TRiC
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NM_002924, NP_002915, P49802-5
UCSC ID: uc001hyv.2
RefSeq Accession: NM_002924
Protein: P49802-5, splice isoform of P49802 CCDS: CCDS31071.1, CCDS60458.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002924.4
exon count: 18CDS single in 3' UTR: no RNA size: 2440
ORF size: 1464CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2327.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.