Asthma C Ober et al. American journal of human genetics 2000, A second-generation genomewide screen for asthma-susceptibility alleles in a founder population., American journal of human genetics.
[PubMed 11022011]
Carotid Arteries Christopher J O'Donnell et al. BMC medical genetics 2007, Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903303]
The results from this GWAS generate hypotheses regarding several SNPs that may be associated with SCA phenotypes in multiple arterial beds. Given the number of tests conducted, subsequent independent replication in a staged approach is essential to identify genetic variants that may be implicated in atherosclerosis.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCG8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK026978 - Homo sapiens cDNA: FLJ23325 fis, clone HEP12505. AK123647 - Homo sapiens cDNA FLJ41653 fis, clone FEBRA2024987, weakly similar to Caenorhabditis elegans Nucampholin (let-858). AB046824 - Homo sapiens KIAA1604 mRNA for KIAA1604 protein. BC041662 - Homo sapiens, Similar to hypothetical protein B230213M24, clone IMAGE:4996115, mRNA. BC053573 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:3873747), partial cds. BC143433 - Homo sapiens cDNA clone IMAGE:9051941. BC093952 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone MGC:120987 IMAGE:7939797), complete cds. BC093954 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone MGC:120989 IMAGE:7939799), complete cds. KJ899368 - Synthetic construct Homo sapiens clone ccsbBroadEn_08762 CWC22 gene, encodes complete protein. AB385487 - Synthetic construct DNA, clone: pF1KA1604, Homo sapiens KIAA1604 gene for KIAA1604 protein, complete cds, without stop codon, in Flexi system. BC016651 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4385766), partial cds. BC031216 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5269056), partial cds. AK025635 - Homo sapiens cDNA: FLJ21982 fis, clone HEP06188. BC057826 - Homo sapiens CWC22 spliceosome-associated protein homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:30334112), partial cds. JD316474 - Sequence 297498 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9HCG8 (Reactome details) participates in the following event(s):
R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA