Human Gene ARFIP1 (uc003imz.3) Description and Page Index
  Description: Homo sapiens ADP-ribosylation factor interacting protein 1 (ARFIP1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:153,701,112-153,833,063 Size: 131,952 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr4:153,750,786-153,831,371 Size: 80,586 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:153,701,112-153,833,063)mRNA (may differ from genome)Protein (373 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Arfaptin-1; AltName: Full=ADP-ribosylation factor-interacting protein 1;
FUNCTION: Putative target protein of ADP-ribosylation factor.
SUBUNIT: Interacts with non-myristoylated GTP-bound ARF3, but not to GDP-bound ARF3, and also to ARF1. Binds with lower affinity to ARF5 and with very little affinity to ARF6.
TISSUE SPECIFICITY: Ubiquitously expressed. Higher levels in liver, pancreas, placenta, skeletal muscle and heart.
SIMILARITY: Contains 1 AH domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.55 RPKM in Cervix - Endocervix
Total median expression: 339.14 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -110.00276-0.399 Picture PostScript Text
3' UTR -428.401692-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010504 - Arfaptin_homology_dom

Pfam Domains:
PF06456 - Arfaptin-like domain

ModBase Predicted Comparative 3D Structure on P53367
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019904 protein domain specific binding
GO:0070273 phosphatidylinositol-4-phosphate binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
GO:0050708 regulation of protein secretion

Cellular Component:
GO:0000139 Golgi membrane
GO:0005829 cytosol
GO:0032588 trans-Golgi network membrane

-  Descriptions from all associated GenBank mRNAs
  AK304141 - Homo sapiens cDNA FLJ53696 complete cds, highly similar to Arfaptin-1.
AK299600 - Homo sapiens cDNA FLJ60846 complete cds, highly similar to Arfaptin-1.
AK290472 - Homo sapiens cDNA FLJ75640 complete cds, highly similar to Homo sapiens ADP-ribosylation factor interacting protein 1(arfaptin 1) (ARFIP1), mRNA.
U52521 - Human arfaptin 1, putative target protein of ADP-ribosylation factor, mRNA, complete cds.
BC103759 - Homo sapiens ADP-ribosylation factor interacting protein 1, mRNA (cDNA clone MGC:117369 IMAGE:6176474), complete cds.
BC105116 - Homo sapiens ADP-ribosylation factor interacting protein 1, mRNA (cDNA clone MGC:132776 IMAGE:8144119), complete cds.
BC105114 - Homo sapiens ADP-ribosylation factor interacting protein 1, mRNA (cDNA clone MGC:132774 IMAGE:8144117), complete cds.
BC143675 - Homo sapiens ADP-ribosylation factor interacting protein 1, mRNA (cDNA clone MGC:177206 IMAGE:9052189), complete cds.
BC143676 - Homo sapiens ADP-ribosylation factor interacting protein 1, mRNA (cDNA clone MGC:177207 IMAGE:9052190), complete cds.
AK096509 - Homo sapiens cDNA FLJ39190 fis, clone OCBBF2004647, highly similar to ARFAPTIN 1.
AF124489 - Homo sapiens arfaptin-1b mRNA, alternatively spliced, complete cds.
AK316125 - Homo sapiens cDNA, FLJ79024 complete cds, highly similar to Arfaptin-1.
JD201350 - Sequence 182374 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARFP1_HUMAN, NM_001025595, NP_001020766, P53367, Q2M2X4, Q3SYL4, Q9Y2X6
UCSC ID: uc003imz.3
RefSeq Accession: NM_001025595
Protein: P53367 (aka ARFP1_HUMAN or AFP1_HUMAN)
CCDS: CCDS34080.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001025595.1
exon count: 9CDS single in 3' UTR: no RNA size: 3091
ORF size: 1122CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2444.00frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.