Human Gene NMD3 (uc003feb.1) Description and Page Index
Description: Homo sapiens NMD3 homolog (S. cerevisiae) (NMD3), mRNA. RefSeq Summary (NM_015938): Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr3:160,939,099-160,969,795 Size: 30,697 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr3:160,939,802-160,968,698 Size: 28,897 Coding Exon Count: 15
ID:NMD3_HUMAN DESCRIPTION: RecName: Full=60S ribosomal export protein NMD3; Short=hNMD3; FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. SUBUNIT: Found in a 60S ribosomal subunit export complex with RAN and XPO1. Interacts with XPO1. Associates with the 60S ribosomal subunit. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus/nucleolus and the cytoplasm in a XPO1/CRM1-dependent manner. SIMILARITY: Belongs to the NMD3 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NMD3 CDC HuGE Published Literature: NMD3 Positive Disease Associations: Body Weight Related Studies:
Body Weight Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96D46
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000055 ribosomal large subunit export from nucleus GO:0015031 protein transport GO:0032092 positive regulation of protein binding GO:1902680 positive regulation of RNA biosynthetic process GO:1904751 positive regulation of protein localization to nucleolus