Human Gene TPGS1 (uc002lou.3)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: TPGS1_HUMAN
DESCRIPTION: RecName: Full=Tubulin polyglutamylase complex subunit 1; Short=PGs1;
FUNCTION: May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). SUBUNIT: Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes (By similarity).
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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ModBase Predicted Comparative 3D Structure on Q6ZTW0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AK126170 - Homo sapiens cDNA FLJ44182 fis, clone THYMU2038369, highly similar to Mus musculus GTRGEO22 (Gtrgeo22) mRNA. AK125401 - Homo sapiens cDNA FLJ43412 fis, clone OCBBF2021323. AB463513 - Synthetic construct DNA, clone: pF1KB7452, Homo sapiens C19orf20 gene for chromosome 19 open reading frame 20, without stop codon, in Flexi system. BC148687 - Synthetic construct Homo sapiens clone IMAGE:100015733, MGC:183160 chromosome 19 open reading frame 20 (C19orf20) mRNA, encodes complete protein. BC152801 - Synthetic construct Homo sapiens clone IMAGE:100016032, MGC:184102 chromosome 19 open reading frame 20 (C19orf20) mRNA, encodes complete protein. JD485621 - Sequence 466645 from Patent EP1572962. BC009520 - Homo sapiens chromosome 19 open reading frame 20, mRNA (cDNA clone IMAGE:3637796), partial cds. JD486921 - Sequence 467945 from Patent EP1572962. JD119020 - Sequence 100044 from Patent EP1572962. JD472020 - Sequence 453044 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Reactome (by CSHL, EBI, and GO)
Protein Q6ZTW0 (Reactome details) participates in the following event(s):
R-HSA-8955869 Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins
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Other Names for This Gene
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Alternate Gene Symbols: C19orf20, NM_033513, NP_277048, Q6ZTW0, Q96GE2, TPGS1_HUMAN UCSC ID: uc002lou.3 RefSeq Accession: NM_033513
Protein: Q6ZTW0
(aka TPGS1_HUMAN)
CCDS: CCDS42454.1
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_033513.2
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exon count:
| 2 | CDS single in 3' UTR:
| no
| RNA size:
| 1134 |
ORF size:
| 873 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 1411.00 | frame shift in genome:
| no
| % Coverage:
| 98.24 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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