Human Gene BCL7C (uc002dzv.3) Description and Page Index
Description: Homo sapiens B-cell CLL/lymphoma 7C (BCL7C), mRNA. RefSeq Summary (NM_004765): This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]. Transcript (Including UTRs) Position: hg19 chr16:30,899,116-30,905,399 Size: 6,284 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr16:30,899,186-30,905,265 Size: 6,080 Coding Exon Count: 6
ID:BCL7C_HUMAN DESCRIPTION: RecName: Full=B-cell CLL/lymphoma 7 protein family member C; FUNCTION: May play an anti-apoptotic role (By similarity). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the BCL7 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): BCL7C CDC HuGE Published Literature: BCL7C
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04714 - BCL7, N-terminal conserver region
ModBase Predicted Comparative 3D Structure on Q8WUZ0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.