Human Gene BCL7C (uc002dzv.3) Description and Page Index
  Description: Homo sapiens B-cell CLL/lymphoma 7C (BCL7C), mRNA.
RefSeq Summary (NM_004765): This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Transcript (Including UTRs)
   Position: hg19 chr16:30,899,116-30,905,399 Size: 6,284 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr16:30,899,186-30,905,265 Size: 6,080 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,899,116-30,905,399)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: BCL7C_HUMAN
DESCRIPTION: RecName: Full=B-cell CLL/lymphoma 7 protein family member C;
FUNCTION: May play an anti-apoptotic role (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the BCL7 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): BCL7C
CDC HuGE Published Literature: BCL7C

-  MalaCards Disease Associations
  MalaCards Gene Search: BCL7C
Diseases sorted by gene-association score: lymphoma (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.95 RPKM in Cervix - Ectocervix
Total median expression: 351.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.10134-0.575 Picture PostScript Text
3' UTR -18.1070-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006804 - BCL7

Pfam Domains:
PF04714 - BCL7, N-terminal conserver region

ModBase Predicted Comparative 3D Structure on Q8WUZ0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006915 apoptotic process


-  Descriptions from all associated GenBank mRNAs
  BC058863 - Homo sapiens B-cell CLL/lymphoma 7C, mRNA (cDNA clone MGC:35095 IMAGE:5167136), complete cds.
HQ448500 - Synthetic construct Homo sapiens clone IMAGE:100071933; CCSB011120_01 B-cell CLL/lymphoma 7C (BCL7C) gene, encodes complete protein.
KJ901961 - Synthetic construct Homo sapiens clone ccsbBroadEn_11355 BCL7C gene, encodes complete protein.
CU691314 - Synthetic construct Homo sapiens gateway clone IMAGE:100021117 5' read BCL7C mRNA.
BC010017 - Homo sapiens cDNA clone IMAGE:2819902, **** WARNING: chimeric clone ****.
BC019071 - Homo sapiens B-cell CLL/lymphoma 7C, mRNA (cDNA clone MGC:29700 IMAGE:4909589), complete cds.
AJ223980 - Homo sapiens mRNA for BCL7C protein.
JF432458 - Synthetic construct Homo sapiens clone IMAGE:100073672 B-cell CLL/lymphoma 7C (BCL7C) gene, encodes complete protein.
KJ892733 - Synthetic construct Homo sapiens clone ccsbBroadEn_02127 BCL7C gene, encodes complete protein.
LF333946 - JP 2014500723-A/141449: Polycomb-Associated Non-Coding RNAs.
HZ483607 - JP 2015535430-A/4113: TERMINALLY MODIFIED RNA.
HZ793538 - JP 2016504050-A/5283: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC516270 - Sequence 6523 from Patent WO2014113089.
LQ073858 - Sequence 4182 from Patent EP2964234.
JD408480 - Sequence 389504 from Patent EP1572962.
JD057662 - Sequence 38686 from Patent EP1572962.
MA647359 - JP 2017113010-A/5283: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA735243 - JP 2017140048-A/4113: TERMINALLY MODIFIED RNA.
MA569523 - JP 2018138019-A/141449: Polycomb-Associated Non-Coding RNAs.
MA804412 - JP 2018183181-A/5283: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Other Names for This Gene
  Alternate Gene Symbols: BCL7C_HUMAN, NM_004765, NP_004756, O43770, Q6PD89, Q8WUZ0
UCSC ID: uc002dzv.3
RefSeq Accession: NM_004765
Protein: Q8WUZ0 (aka BCL7C_HUMAN)
CCDS: CCDS10693.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004765.2
exon count: 6CDS single in 3' UTR: no RNA size: 877
ORF size: 654CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1508.00frame shift in genome: no % Coverage: 97.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.