Human Gene ERGIC2 (uc001riv.3) Description and Page Index
Description: Homo sapiens ERGIC and golgi 2 (ERGIC2), mRNA. RefSeq Summary (NM_016570): ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.452088.1, AL834128.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000360150.9/ ENSP00000353270.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr12:29,493,579-29,534,143 Size: 40,565 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr12:29,494,089-29,524,566 Size: 30,478 Coding Exon Count: 13
ID:ERGI2_HUMAN DESCRIPTION: RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein 2; FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi (By similarity). SUBUNIT: May interact with EEF1A1. SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. PubMed:11445006 states that it localizes to the nucleus; PubMed:17980171 shows a partial localization in the nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the ERGIC family. SEQUENCE CAUTION: Sequence=AAF61208.1; Type=Frameshift; Positions=202, 209, 212;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96RQ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.