Human Gene TMEM223 (uc001nve.2) Description and Page Index
  Description: Homo sapiens transmembrane protein 223 (TMEM223), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:62,557,787-62,559,486 Size: 1,700 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr11:62,558,095-62,559,466 Size: 1,372 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:62,557,787-62,559,486)mRNA (may differ from genome)Protein (202 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transmembrane protein 223;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM223 family.
SEQUENCE CAUTION: Sequence=AAH20914.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM223
CDC HuGE Published Literature: TMEM223

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.68 RPKM in Adrenal Gland
Total median expression: 394.60 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -2.9020-0.145 Picture PostScript Text
3' UTR -90.98308-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026100 - Tmem223

Pfam Domains:
PF14640 - Transmembrane protein 223

ModBase Predicted Comparative 3D Structure on A0PJW6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  Protein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007399 nervous system development

Cellular Component:
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC035565 - Homo sapiens hypothetical protein MGC3196, mRNA (cDNA clone IMAGE:5176412), partial cds.
BC042801 - Homo sapiens transmembrane protein 223, mRNA (cDNA clone IMAGE:5284113), partial cds.
BC071957 - Homo sapiens cDNA clone IMAGE:6110626, partial cds.
BC008643 - Homo sapiens transmembrane protein 223, mRNA (cDNA clone IMAGE:3855124), partial cds.
BC094837 - Homo sapiens transmembrane protein 223, mRNA (cDNA clone IMAGE:6429565), partial cds.
BC020914 - Homo sapiens transmembrane protein 223, mRNA (cDNA clone IMAGE:4762400), partial cds.
BC127679 - Homo sapiens transmembrane protein 223, mRNA (cDNA clone MGC:157766 IMAGE:40127503), complete cds.
LF375576 - JP 2014500723-A/183079: Polycomb-Associated Non-Coding RNAs.
KJ894643 - Synthetic construct Homo sapiens clone ccsbBroadEn_04037 TMEM223 gene, encodes complete protein.
JD025940 - Sequence 6964 from Patent EP1572962.
JD034686 - Sequence 15710 from Patent EP1572962.
JD020208 - Sequence 1232 from Patent EP1572962.
JD029591 - Sequence 10615 from Patent EP1572962.
MA611153 - JP 2018138019-A/183079: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJW6, NM_001080501, NP_001073970, Q504S0, Q86YD4, Q8WUC5, Q96HG0, TM223_HUMAN
UCSC ID: uc001nve.2
RefSeq Accession: NM_001080501
Protein: A0PJW6 (aka TM223_HUMAN)
CCDS: CCDS44628.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001080501.2
exon count: 2CDS single in 3' UTR: no RNA size: 954
ORF size: 609CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1418.00frame shift in genome: no % Coverage: 98.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.