Human Gene DUSP12 (uc001gbo.3) Description and Page Index
  Description: Homo sapiens dual specificity phosphatase 12 (DUSP12), mRNA.
RefSeq Summary (NM_007240): The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.260539.1, DRR138512.99368.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:161,719,581-161,726,952 Size: 7,372 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr1:161,719,592-161,726,737 Size: 7,146 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:161,719,581-161,726,952)mRNA (may differ from genome)Protein (340 aa)
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Wikipedia

-  Comments and Description Text from UniProtKB
  ID: DUS12_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 12; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity tyrosine phosphatase YVH1;
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
COFACTOR: Binds 2 zinc ions per subunit.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DUSP12
CDC HuGE Published Literature: DUSP12
Positive Disease Associations: diabetes, type 2 , Neuroblastoma
Related Studies:
  1. diabetes, type 2
    Das, S. K. et al. 2006, Polymorphisms in the Glucokinase-Associated, Dual-Specificity Phosphatase 12 (DUSP12) Gene Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes, Diabetes 2006 55(9) 2631-9. [PubMed 16936214]
  2. Neuroblastoma
    , , . [PubMed 0]
  3. Neuroblastoma
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.40 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 411.62 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -39.96215-0.186 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR016278 - DUSP12
IPR000387 - Tyr/Dual-specificity_Pase
IPR007087 - Znf_C2H2

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

ModBase Predicted Comparative 3D Structure on Q9UNI6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019900 kinase binding
GO:0046872 metal ion binding

Biological Process:
GO:0006464 cellular protein modification process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0033133 positive regulation of glucokinase activity
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  LF205447 - JP 2014500723-A/12950: Polycomb-Associated Non-Coding RNAs.
BC006286 - Homo sapiens dual specificity phosphatase 12, mRNA (cDNA clone MGC:10337 IMAGE:3958403), complete cds.
JD278268 - Sequence 259292 from Patent EP1572962.
AF119226 - Homo sapiens dual-specificity tyrosine phosphatase YVH1 mRNA, complete cds.
DQ892766 - Synthetic construct clone IMAGE:100005396; FLH189482.01X; RZPDo839F0874D dual specificity phosphatase 12 (DUSP12) gene, encodes complete protein.
DQ896011 - Synthetic construct Homo sapiens clone IMAGE:100010471; FLH189478.01L; RZPDo839F0864D dual specificity phosphatase 12 (DUSP12) gene, encodes complete protein.
CU675333 - Synthetic construct Homo sapiens gateway clone IMAGE:100019009 5' read DUSP12 mRNA.
KJ893268 - Synthetic construct Homo sapiens clone ccsbBroadEn_02662 DUSP12 gene, encodes complete protein.
BT006633 - Homo sapiens dual specificity phosphatase 12 mRNA, complete cds.
LF320680 - JP 2014500723-A/128183: Polycomb-Associated Non-Coding RNAs.
AK000259 - Homo sapiens cDNA FLJ20252 fis, clone COLF6726.
JD020960 - Sequence 1984 from Patent EP1572962.
JD032286 - Sequence 13310 from Patent EP1572962.
JD328361 - Sequence 309385 from Patent EP1572962.
JD369721 - Sequence 350745 from Patent EP1572962.
MA441024 - JP 2018138019-A/12950: Polycomb-Associated Non-Coding RNAs.
MA556257 - JP 2018138019-A/128183: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DUS12_HUMAN, NM_007240, NP_009171, Q5VXA8, Q9UNI6
UCSC ID: uc001gbo.3
RefSeq Accession: NM_007240
Protein: Q9UNI6 (aka DUS12_HUMAN or DUSC_HUMAN)
CCDS: CCDS1234.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_007240.1
exon count: 6CDS single in 3' UTR: no RNA size: 1271
ORF size: 1023CDS single in intron: no Alignment % ID: 99.84
txCdsPredict score: 2246.00frame shift in genome: no % Coverage: 98.27
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.