Human Gene IKZF5 (uc021qaj.2) Description and Page Index
  Description: Homo sapiens IKAROS family zinc finger 5 (Pegasus) (IKZF5), transcript variant 1, mRNA.
RefSeq Summary (NM_001271840): Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002].
Transcript (Including UTRs)
   Position: hg19 chr10:124,750,322-124,768,203 Size: 17,882 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr10:124,753,296-124,758,141 Size: 4,846 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:124,750,322-124,768,203)mRNA (may differ from genome)Protein (419 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IKZF5_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein Pegasus; AltName: Full=Ikaros family zinc finger protein 5;
FUNCTION: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.
SUBUNIT: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT- 4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
DOMAIN: The N-terminal zinc fingers are involved in sequence- specific DNA binding and heterotypic associations with other family members.
DOMAIN: C-terminal zinc fingers mediate homodimerization.
MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.
SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.17 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 168.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -95.80310-0.309 Picture PostScript Text
3' UTR -681.932974-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9H5V7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051291 protein heterooligomerization

Cellular Component:
GO:0005634 nucleus
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  AK122899 - Homo sapiens cDNA FLJ16565 fis, clone SYNOV4007711, highly similar to Homo sapiens zinc finger protein, subfamily 1A, 5 (ZNFN1A5), mRNA.
AK055507 - Homo sapiens cDNA FLJ30945 fis, clone FEBRA2007613.
LP895215 - Sequence 79 from Patent EP3253886.
CR749800 - Homo sapiens mRNA; cDNA DKFZp781B0249 (from clone DKFZp781B0249).
AK023288 - Homo sapiens cDNA FLJ13226 fis, clone OVARC1000068.
LF376115 - JP 2014500723-A/183618: Polycomb-Associated Non-Coding RNAs.
BX647958 - Homo sapiens mRNA; cDNA DKFZp686M0751 (from clone DKFZp686M0751).
BC022564 - Homo sapiens IKAROS family zinc finger 5 (Pegasus), mRNA (cDNA clone IMAGE:4796825).
JD280122 - Sequence 261146 from Patent EP1572962.
JD203074 - Sequence 184098 from Patent EP1572962.
JD556846 - Sequence 537870 from Patent EP1572962.
JD521561 - Sequence 502585 from Patent EP1572962.
JD492923 - Sequence 473947 from Patent EP1572962.
JD496133 - Sequence 477157 from Patent EP1572962.
JD298557 - Sequence 279581 from Patent EP1572962.
AK226143 - Homo sapiens mRNA for zinc finger protein, subfamily 1A, 5 variant, clone: pj02180.
JD264097 - Sequence 245121 from Patent EP1572962.
JD564206 - Sequence 545230 from Patent EP1572962.
AK026626 - Homo sapiens cDNA: FLJ22973 fis, clone KAT11042.
JD299067 - Sequence 280091 from Patent EP1572962.
KJ903074 - Synthetic construct Homo sapiens clone ccsbBroadEn_12468 IKZF5 gene, encodes complete protein.
DQ892400 - Synthetic construct clone IMAGE:100005030; FLH185998.01X; RZPDo839H08148D zinc finger protein, subfamily 1A, 5 (ZNFN1A5) gene, encodes complete protein.
DQ895614 - Synthetic construct Homo sapiens clone IMAGE:100010074; FLH185994.01L; RZPDo839H08147D zinc finger protein, subfamily 1A, 5 (ZNFN1A5) gene, encodes complete protein.
AF230808 - Homo sapiens zinc finger transcription factor Pegasus mRNA, complete cds.
AB463773 - Synthetic construct DNA, clone: pF1KB7705, Homo sapiens IKZF5 gene for IKAROS family zinc finger 5, without stop codon, in Flexi system.
CU692700 - Synthetic construct Homo sapiens gateway clone IMAGE:100019319 5' read IKZF5 mRNA.
JD240984 - Sequence 222008 from Patent EP1572962.
JD512337 - Sequence 493361 from Patent EP1572962.
MA611692 - JP 2018138019-A/183618: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KVH7, D3DRE7, IKZF5_HUMAN, NM_001271840, NP_001258769, Q9H2T0, Q9H5V7, uc021qaj.1, ZNFN1A5
UCSC ID: uc021qaj.2
RefSeq Accession: NM_001271840
Protein: Q9H5V7 (aka IKZF5_HUMAN)
CCDS: CCDS41574.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001271840.1
exon count: 5CDS single in 3' UTR: no RNA size: 4553
ORF size: 1260CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2588.50frame shift in genome: no % Coverage: 99.80
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.