Human Gene IKZF5 (uc021qaj.2) Description and Page Index
Description: Homo sapiens IKAROS family zinc finger 5 (Pegasus) (IKZF5), transcript variant 1, mRNA. RefSeq Summary (NM_001271840): Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]. Transcript (Including UTRs) Position: hg19 chr10:124,750,322-124,768,203 Size: 17,882 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr10:124,753,296-124,758,141 Size: 4,846 Coding Exon Count: 3
ID:IKZF5_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein Pegasus; AltName: Full=Ikaros family zinc finger protein 5; FUNCTION: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor. SUBUNIT: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT- 4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. DOMAIN: The N-terminal zinc fingers are involved in sequence- specific DNA binding and heterotypic associations with other family members. DOMAIN: C-terminal zinc fingers mediate homodimerization. MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology. SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H5V7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0008270 zinc ion binding GO:0019904 protein domain specific binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0051291 protein heterooligomerization