Human Gene MGA (uc010ucy.2) Description and Page Index
  Description: Homo sapiens MGA, MAX dimerization protein (MGA), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:41,952,610-42,062,141 Size: 109,532 Total Exon Count: 24 Strand: +
Coding Region
   Position: hg19 chr15:41,961,093-42,059,478 Size: 98,386 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:41,952,610-42,062,141)mRNA (may differ from genome)Protein (3065 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E7ENI0_HUMAN
DESCRIPTION: SubName: Full=MAX gene-associated protein;
SIMILARITY: Contains 1 T-box DNA-binding domain.
SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: MGA
Diseases sorted by gene-association score: aicardi-goutieres syndrome (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.33 RPKM in Testis
Total median expression: 156.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -64.30181-0.355 Picture PostScript Text
3' UTR -732.172663-0.275 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom
IPR008967 - p53-like_TF_DNA-bd
IPR001699 - TF_T-box
IPR018186 - TF_T-box_CS

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain
PF00907 - T-box
PF16059 - Domain of unknown function (DUF4801)

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain
49417 - p53-like transcription factors

ModBase Predicted Comparative 3D Structure on E7ENI0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF205849 - JP 2014500723-A/13352: Polycomb-Associated Non-Coding RNAs.
AK055203 - Homo sapiens cDNA FLJ30641 fis, clone CTONG2002820, highly similar to Mus musculus MGA protein mRNA.
BC136659 - Homo sapiens MAX gene associated, mRNA (cDNA clone MGC:168272 IMAGE:9020649), complete cds.
AK022696 - Homo sapiens cDNA FLJ12634 fis, clone NT2RM4001858, weakly similar to T-BOX CONTAINING PROTEIN TBX6L.
AK025751 - Homo sapiens cDNA: FLJ22098 fis, clone HEP17040.
BC007584 - Homo sapiens MAX gene associated, mRNA (cDNA clone IMAGE:3140424), partial cds.
AK301207 - Homo sapiens cDNA FLJ55596 partial cds, moderately similar to Mus musculus MAX gene associated (Mga), mRNA.
AL713737 - Homo sapiens mRNA; cDNA DKFZp667M0810 (from clone DKFZp667M0810).
AK056470 - Homo sapiens cDNA FLJ31908 fis, clone NT2RP7004541, moderately similar to Mus musculus MGA protein mRNA.
JD525074 - Sequence 506098 from Patent EP1572962.
JD046019 - Sequence 27043 from Patent EP1572962.
JD393814 - Sequence 374838 from Patent EP1572962.
JD250769 - Sequence 231793 from Patent EP1572962.
BX648098 - Homo sapiens mRNA; cDNA DKFZp686C0440 (from clone DKFZp686C0440).
AK023360 - Homo sapiens cDNA FLJ13298 fis, clone OVARC1001306, weakly similar to N-MYC PROTO-ONCOGENE PROTEIN.
AB011090 - Homo sapiens mRNA for KIAA0518 protein, partial cds.
AL050181 - Homo sapiens mRNA; cDNA DKFZp586A1123 (from clone DKFZp586A1123).
JD348367 - Sequence 329391 from Patent EP1572962.
JD174922 - Sequence 155946 from Patent EP1572962.
JD403864 - Sequence 384888 from Patent EP1572962.
JD238774 - Sequence 219798 from Patent EP1572962.
JD264412 - Sequence 245436 from Patent EP1572962.
JD049038 - Sequence 30062 from Patent EP1572962.
JD327370 - Sequence 308394 from Patent EP1572962.
JD286554 - Sequence 267578 from Patent EP1572962.
JD207367 - Sequence 188391 from Patent EP1572962.
JD410806 - Sequence 391830 from Patent EP1572962.
JD100168 - Sequence 81192 from Patent EP1572962.
BC016982 - Homo sapiens, clone IMAGE:4185110, mRNA.
JD302948 - Sequence 283972 from Patent EP1572962.
JD386907 - Sequence 367931 from Patent EP1572962.
JD360490 - Sequence 341514 from Patent EP1572962.
JD318009 - Sequence 299033 from Patent EP1572962.
JD066890 - Sequence 47914 from Patent EP1572962.
JD235593 - Sequence 216617 from Patent EP1572962.
JD490852 - Sequence 471876 from Patent EP1572962.
JD428165 - Sequence 409189 from Patent EP1572962.
JD557903 - Sequence 538927 from Patent EP1572962.
JD200812 - Sequence 181836 from Patent EP1572962.
JD496389 - Sequence 477413 from Patent EP1572962.
JD521467 - Sequence 502491 from Patent EP1572962.
JD512251 - Sequence 493275 from Patent EP1572962.
JD126382 - Sequence 107406 from Patent EP1572962.
JD080666 - Sequence 61690 from Patent EP1572962.
JD528623 - Sequence 509647 from Patent EP1572962.
JD168236 - Sequence 149260 from Patent EP1572962.
JD268258 - Sequence 249282 from Patent EP1572962.
JD348503 - Sequence 329527 from Patent EP1572962.
JD338250 - Sequence 319274 from Patent EP1572962.
JD562816 - Sequence 543840 from Patent EP1572962.
MA441426 - JP 2018138019-A/13352: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: E7ENI0, E7ENI0_HUMAN, NM_001164273, NP_001157745
UCSC ID: uc010ucy.2
RefSeq Accession: NM_001164273
Protein: E7ENI0 CCDS: CCDS55959.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001164273.1
exon count: 24CDS single in 3' UTR: no RNA size: 12042
ORF size: 9198CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 16522.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.