Human Gene ZNF397 (uc010dmp.3) Description and Page Index
Description: Homo sapiens zinc finger protein 397 (ZNF397), transcript variant 1, mRNA. RefSeq Summary (NM_001135178): This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr18:32,820,994-32,827,153 Size: 6,160 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr18:32,822,435-32,826,274 Size: 3,840 Coding Exon Count: 3
ID:ZN397_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 397; AltName: Full=Zinc finger and SCAN domain-containing protein 15; AltName: Full=Zinc finger protein 47; FUNCTION: Isoform 3 acts as a DNA-dependent transcriptional repressor. SUBUNIT: Isoforms 1 and 3 can both homo- and hetero-associate. Homo-association of isoform 1 is dependent on the presence of the SCAN domain. SUBCELLULAR LOCATION: Isoform 1: Nucleus. SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Expressed strongly in testis, moderately in skeletal muscle, pancreas and prostate, and weakly in heart, placenta, liver, kidney, spleen, thymus and small intestine. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 9 C2H2-type zinc fingers. SIMILARITY: Contains 1 SCAN box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NF99
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0045892 negative regulation of transcription, DNA-templated