Human Gene SEC22A (uc003ege.3) Description and Page Index
Description: Homo sapiens SEC22 vesicle trafficking protein homolog A (S. cerevisiae) (SEC22A), mRNA. RefSeq Summary (NM_012430): The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.96762.1, SRR1803617.119793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000492595.6/ ENSP00000417972.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr3:122,920,774-122,992,982 Size: 72,209 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr3:122,928,065-122,990,569 Size: 62,505 Coding Exon Count: 6
ID:SC22A_HUMAN DESCRIPTION: RecName: Full=Vesicle-trafficking protein SEC22a; AltName: Full=SEC22 vesicle-trafficking protein homolog A; AltName: Full=SEC22 vesicle-trafficking protein-like 2; FUNCTION: May be involved in vesicle transport between the ER and the Golgi complex (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SIMILARITY: Belongs to the synaptobrevin family. SIMILARITY: Contains 1 longin domain. SEQUENCE CAUTION: Sequence=AAD43013.1; Type=Frameshift; Positions=265, 288;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): SEC22A CDC HuGE Published Literature: SEC22A
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96IW7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.