Human Gene RPP30 (uc001khd.2) Description and Page Index
  Description: Homo sapiens ribonuclease P/MRP 30kDa subunit (RPP30), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:92,631,474-92,668,312 Size: 36,839 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr10:92,631,744-92,663,019 Size: 31,276 Coding Exon Count: 13 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:92,631,474-92,668,312)mRNA (may differ from genome)Protein (322 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): RPP30
CDC HuGE Published Literature: RPP30
Positive Disease Associations: Glucose
Related Studies:
  1. Glucose
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: RPP30
Diseases sorted by gene-association score: omenn syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.32 RPKM in Testis
Total median expression: 167.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.50270-0.298 Picture PostScript Text
3' UTR -931.823268-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016195 - Pol/histidinol_Pase-like
IPR002738 - RNase_P_p30

Pfam Domains:
PF01876 - RNase P subunit p30

SCOP Domains:
89550 - PHP domain-like

ModBase Predicted Comparative 3D Structure on E9PB02
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene Details  Gene DetailsGene DetailsGene Details
Gene Sorter  Gene SorterGene SorterGene Sorter
  EnsemblFlyBaseWormBaseSGD
  Protein SequenceProtein SequenceProtein SequenceProtein Sequence
  AlignmentAlignmentAlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  AK095810 - Homo sapiens cDNA FLJ38491 fis, clone FEBRA2023990.
BC006991 - Homo sapiens ribonuclease P/MRP 30kDa subunit, mRNA (cDNA clone MGC:12256 IMAGE:3827681), complete cds.
JD530745 - Sequence 511769 from Patent EP1572962.
JD508960 - Sequence 489984 from Patent EP1572962.
JD559849 - Sequence 540873 from Patent EP1572962.
AL833628 - Homo sapiens mRNA; cDNA DKFZp686C1579 (from clone DKFZp686C1579).
AK296196 - Homo sapiens cDNA FLJ57382 complete cds, highly similar to Ribonuclease P protein subunit p30 (EC 3.1.26.5).
U77665 - Human RNaseP protein p30 (RPP30) mRNA, complete cds.
AK312900 - Homo sapiens cDNA, FLJ93346, Homo sapiens ribonuclease P (30kD) (RPP30), mRNA.
AK225532 - Homo sapiens mRNA for ribonuclease P variant, clone: KAT10347.
KJ893074 - Synthetic construct Homo sapiens clone ccsbBroadEn_02468 RPP30 gene, encodes complete protein.
DQ893181 - Synthetic construct clone IMAGE:100005811; FLH194795.01X; RZPDo839F0280D ribonuclease P/MRP 30kDa subunit (RPP30) gene, encodes complete protein.
DQ896488 - Synthetic construct Homo sapiens clone IMAGE:100010948; FLH194791.01L; RZPDo839F0270D ribonuclease P/MRP 30kDa subunit (RPP30) gene, encodes complete protein.
JD380447 - Sequence 361471 from Patent EP1572962.
BC044601 - Homo sapiens cDNA clone IMAGE:4815080.
JD501618 - Sequence 482642 from Patent EP1572962.
JD091458 - Sequence 72482 from Patent EP1572962.
JD150744 - Sequence 131768 from Patent EP1572962.
JD240377 - Sequence 221401 from Patent EP1572962.
JD339555 - Sequence 320579 from Patent EP1572962.
JD351163 - Sequence 332187 from Patent EP1572962.
JD544764 - Sequence 525788 from Patent EP1572962.
JD044567 - Sequence 25591 from Patent EP1572962.
JD304436 - Sequence 285460 from Patent EP1572962.
JD110087 - Sequence 91111 from Patent EP1572962.
JD065652 - Sequence 46676 from Patent EP1572962.
JD203887 - Sequence 184911 from Patent EP1572962.
JD471119 - Sequence 452143 from Patent EP1572962.
JD160546 - Sequence 141570 from Patent EP1572962.
JD108451 - Sequence 89475 from Patent EP1572962.
JD309414 - Sequence 290438 from Patent EP1572962.
JD473794 - Sequence 454818 from Patent EP1572962.
JD066848 - Sequence 47872 from Patent EP1572962.
JD271044 - Sequence 252068 from Patent EP1572962.
JD252427 - Sequence 233451 from Patent EP1572962.
JD166483 - Sequence 147507 from Patent EP1572962.
JD274384 - Sequence 255408 from Patent EP1572962.
JD252925 - Sequence 233949 from Patent EP1572962.
JD303012 - Sequence 284036 from Patent EP1572962.
JD297289 - Sequence 278313 from Patent EP1572962.
JD308324 - Sequence 289348 from Patent EP1572962.
JD438044 - Sequence 419068 from Patent EP1572962.
JD142755 - Sequence 123779 from Patent EP1572962.
JD561751 - Sequence 542775 from Patent EP1572962.
JD552153 - Sequence 533177 from Patent EP1572962.
JD133261 - Sequence 114285 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PB02, E9PB02_HUMAN, NM_001104546, NP_001098016
UCSC ID: uc001khd.2
RefSeq Accession: NM_001104546
Protein: E9PB02 CCDS: CCDS44458.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001104546.1
exon count: 14CDS single in 3' UTR: no RNA size: 4272
ORF size: 969CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1954.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.