Human Gene ENDOV (uc021ueo.1) Description and Page Index
  Description: Homo sapiens endonuclease V (ENDOV), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:78,388,967-78,411,884 Size: 22,918 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr17:78,388,995-78,409,943 Size: 20,949 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:78,388,967-78,411,884)mRNA (may differ from genome)Protein (282 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Endonuclease V; EC=3.1.21.-;
FUNCTION: Selectively cleaves DNA at the second phosphodiester bond 3' to hypoxanthine- and uracil-containing nucleotides. Shows higher activity towards single-stranded than double-stranded DNA and towards hypoxanthine than uracil (By similarity).
COFACTOR: Magnesium (By similarity).
SIMILARITY: Belongs to the endonuclease V family.

-  MalaCards Disease Associations
  MalaCards Gene Search: ENDOV
Diseases sorted by gene-association score: uv-sensitive syndrome (7)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.57 RPKM in Testis
Total median expression: 156.37 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.1028-0.146 Picture PostScript Text
3' UTR -700.911941-0.361 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007581 - Endonuclease-V

Pfam Domains:
PF04493 - Endonuclease V

ModBase Predicted Comparative 3D Structure on Q8N8Q3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters
GO:0046872 metal ion binding

Biological Process:
GO:0006281 DNA repair
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  HQ448107 - Synthetic construct Homo sapiens clone IMAGE:100071487; CCSB012216_03 hypothetical protein FLJ35220 (FLJ35220) gene, encodes complete protein.
KJ895981 - Synthetic construct Homo sapiens clone ccsbBroadEn_05375 ENDOV gene, encodes complete protein.
AK092539 - Homo sapiens cDNA FLJ35220 fis, clone PROST2000760, weakly similar to PUTATIVE ENDONUCLEASE C1F12.06C (EC 3.1.-.-).
AK096344 - Homo sapiens cDNA FLJ39025 fis, clone NT2RP7004559, weakly similar to ENDONUCLEASE C1F12.06C (EC 3.1.-.-).
AX747589 - Sequence 1114 from Patent EP1308459.
BC059781 - Homo sapiens cDNA clone IMAGE:5171827, partial cds.
BC064545 - Homo sapiens hypothetical protein FLJ35220, mRNA (cDNA clone MGC:74455 IMAGE:5736957), complete cds.
AK123689 - Homo sapiens cDNA FLJ41695 fis, clone HCHON2001548.
BX647411 - Homo sapiens mRNA; cDNA DKFZp686O18152 (from clone DKFZp686O18152).
BC037889 - Homo sapiens hypothetical protein FLJ35220, mRNA (cDNA clone IMAGE:5275049), complete cds.
BC045824 - Homo sapiens hypothetical protein FLJ35220, mRNA (cDNA clone IMAGE:5261279), complete cds.
AK056045 - Homo sapiens cDNA FLJ31483 fis, clone NT2NE2001677.
AK096802 - Homo sapiens cDNA FLJ39483 fis, clone PROST2014916.
JD414244 - Sequence 395268 from Patent EP1572962.
JD185892 - Sequence 166916 from Patent EP1572962.
JD231797 - Sequence 212821 from Patent EP1572962.
JD279221 - Sequence 260245 from Patent EP1572962.
JD551764 - Sequence 532788 from Patent EP1572962.
JD207221 - Sequence 188245 from Patent EP1572962.
JD310330 - Sequence 291354 from Patent EP1572962.
JD367966 - Sequence 348990 from Patent EP1572962.
JD229859 - Sequence 210883 from Patent EP1572962.
JD081034 - Sequence 62058 from Patent EP1572962.
JD353660 - Sequence 334684 from Patent EP1572962.
JD470384 - Sequence 451408 from Patent EP1572962.
JD256361 - Sequence 237385 from Patent EP1572962.
JD269034 - Sequence 250058 from Patent EP1572962.
JD470035 - Sequence 451059 from Patent EP1572962.
JD451826 - Sequence 432850 from Patent EP1572962.
JD056392 - Sequence 37416 from Patent EP1572962.
JD483476 - Sequence 464500 from Patent EP1572962.
JD475470 - Sequence 456494 from Patent EP1572962.
JD235473 - Sequence 216497 from Patent EP1572962.
JD544163 - Sequence 525187 from Patent EP1572962.
JD294675 - Sequence 275699 from Patent EP1572962.
JD282050 - Sequence 263074 from Patent EP1572962.
JD076826 - Sequence 57850 from Patent EP1572962.
JD244707 - Sequence 225731 from Patent EP1572962.
JD214127 - Sequence 195151 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENDOV_HUMAN, NM_173627, NP_775898, Q6P2G2, Q86X99, Q8N8Q3, Q8NAK0
UCSC ID: uc021ueo.1
RefSeq Accession: NM_173627
Protein: Q8N8Q3 (aka ENDOV_HUMAN)
CCDS: CCDS54172.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_173627.3
exon count: 10CDS single in 3' UTR: no RNA size: 2840
ORF size: 849CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1783.00frame shift in genome: no % Coverage: 99.23
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.