Human Gene ZNF653 (uc002mrz.2) Description and Page Index
  Description: Homo sapiens zinc finger protein 653 (ZNF653), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:11,594,242-11,616,738 Size: 22,497 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr19:11,594,497-11,616,601 Size: 22,105 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:11,594,242-11,616,738)mRNA (may differ from genome)Protein (615 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Zinc finger protein 653; AltName: Full=67 kDa zinc finger protein; AltName: Full=Zinc finger protein Zip67;
FUNCTION: Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
SUBUNIT: Interacts with NR5A1.
TISSUE SPECIFICITY: Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.31 RPKM in Testis
Total median expression: 202.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.50137-0.412 Picture PostScript Text
3' UTR -99.61255-0.391 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017956 - AT_hook_DNA-bd_motif
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q96CK0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0046872 metal ion binding
GO:0048019 receptor antagonist activity
GO:0050682 AF-2 domain binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:1900116 extracellular negative regulation of signal transduction
GO:1903507 negative regulation of nucleic acid-templated transcription

Cellular Component:
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  LF384526 - JP 2014500723-A/192029: Polycomb-Associated Non-Coding RNAs.
AY072704 - Homo sapiens zinc finger protein Zip67 mRNA, complete cds.
AK131037 - Homo sapiens cDNA FLJ29003 fis, clone CBL01204.
JD442255 - Sequence 423279 from Patent EP1572962.
BC016816 - Homo sapiens zinc finger protein 653, mRNA (cDNA clone MGC:24494 IMAGE:4094670), complete cds.
BC014187 - Homo sapiens zinc finger protein 653, mRNA (cDNA clone MGC:20975 IMAGE:4634585), complete cds.
JD456672 - Sequence 437696 from Patent EP1572962.
HQ258023 - Synthetic construct Homo sapiens clone IMAGE:100072332 zinc finger protein 653 (ZNF653) gene, encodes complete protein.
KJ895296 - Synthetic construct Homo sapiens clone ccsbBroadEn_04690 ZNF653 gene, encodes complete protein.
AK314986 - Homo sapiens cDNA, FLJ95907.
LF375835 - JP 2014500723-A/183338: Polycomb-Associated Non-Coding RNAs.
JD125254 - Sequence 106278 from Patent EP1572962.
JD462439 - Sequence 443463 from Patent EP1572962.
LF375836 - JP 2014500723-A/183339: Polycomb-Associated Non-Coding RNAs.
MA620103 - JP 2018138019-A/192029: Polycomb-Associated Non-Coding RNAs.
MA611412 - JP 2018138019-A/183338: Polycomb-Associated Non-Coding RNAs.
MA611413 - JP 2018138019-A/183339: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_138783, NP_620138, Q96AS7, Q96CK0, ZIP67, ZN653_HUMAN
UCSC ID: uc002mrz.2
RefSeq Accession: NM_138783
Protein: Q96CK0 (aka ZN653_HUMAN)
CCDS: CCDS12261.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_138783.3
exon count: 9CDS single in 3' UTR: no RNA size: 2255
ORF size: 1848CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3848.00frame shift in genome: no % Coverage: 99.33
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.