Human Gene MOK (uc001ylm.4) Description and Page Index
  Description: Homo sapiens MOK protein kinase (MOK), transcript variant 1, mRNA.
RefSeq Summary (NM_014226): This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB022694.1, SRR1660807.5175.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361847.7/ ENSP00000355304.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr14:102,695,158-102,771,537 Size: 76,380 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr14:102,695,626-102,771,305 Size: 75,680 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:102,695,158-102,771,537)mRNA (may differ from genome)Protein (419 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MOK_HUMAN
DESCRIPTION: RecName: Full=MAPK/MAK/MRK overlapping kinase; EC=2.7.11.22; AltName: Full=MOK protein kinase; AltName: Full=Renal tumor antigen 1; Short=RAGE-1;
FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Phosphorylation appears to increase the enzymatic activity (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
PTM: Autophosphorylated (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAB38087.1; Type=Frameshift; Positions=299;

-  MalaCards Disease Associations
  MalaCards Gene Search: MOK
Diseases sorted by gene-association score: renal cell carcinoma (5), kidney cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.05 RPKM in Testis
Total median expression: 153.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.00232-0.397 Picture PostScript Text
3' UTR -171.22468-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9UQ07
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010468 regulation of gene expression
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0042995 cell projection
GO:0097546 ciliary base


-  Descriptions from all associated GenBank mRNAs
  LF209662 - JP 2014500723-A/17165: Polycomb-Associated Non-Coding RNAs.
AK094747 - Homo sapiens cDNA FLJ37428 fis, clone BRAWH2001662, highly similar to Homo sapiens mRNA for MOK protein kinase.
BC026069 - Homo sapiens renal tumor antigen, mRNA (cDNA clone MGC:26281 IMAGE:4838296), complete cds.
BC053536 - Homo sapiens renal tumor antigen, mRNA (cDNA clone MGC:61453 IMAGE:5175851), complete cds.
AB022694 - Homo sapiens mRNA for MOK protein kinase, complete cds.
AK302349 - Homo sapiens cDNA FLJ52803 complete cds, highly similar to MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22).
AK312778 - Homo sapiens cDNA, FLJ93194, highly similar to Homo sapiens renal tumor antigen (RAGE), mRNA.
MA445239 - JP 2018138019-A/17165: Polycomb-Associated Non-Coding RNAs.
U46194 - Human renal cell carcinoma antigen RAGE-4 mRNA, complete putative cds.
AK094003 - Homo sapiens cDNA FLJ36684 fis, clone UTERU2007942.
U46193 - Human renal cell carcinoma antigen RAGE-3 mRNA, complete putative cds.
BC043179 - Homo sapiens renal tumor antigen, mRNA (cDNA clone MGC:44179 IMAGE:5287879), complete cds.
U46191 - Human renal cell carcinoma antigen RAGE-1 mRNA, complete putative cds.
U46192 - Human renal cell carcinoma antigen RAGE-2 mRNA, complete putative cds.
AK131542 - Homo sapiens cDNA FLJ16778 fis, clone BRHIP3030064, moderately similar to Homo sapiens renal tumor antigen (RAGE).
JD170740 - Sequence 151764 from Patent EP1572962.
JD042236 - Sequence 23260 from Patent EP1572962.
JD235649 - Sequence 216673 from Patent EP1572962.
JD405129 - Sequence 386153 from Patent EP1572962.
KJ904545 - Synthetic construct Homo sapiens clone ccsbBroadEn_13939 MOK gene, encodes complete protein.
KJ905304 - Synthetic construct Homo sapiens clone ccsbBroadEn_14824 MOK gene, encodes complete protein.
CU690976 - Synthetic construct Homo sapiens gateway clone IMAGE:100021580 5' read RAGE mRNA.
LF330625 - JP 2014500723-A/138128: Polycomb-Associated Non-Coding RNAs.
LF330627 - JP 2014500723-A/138130: Polycomb-Associated Non-Coding RNAs.
MA566202 - JP 2018138019-A/138128: Polycomb-Associated Non-Coding RNAs.
MA566204 - JP 2018138019-A/138130: Polycomb-Associated Non-Coding RNAs.
LF330630 - JP 2014500723-A/138133: Polycomb-Associated Non-Coding RNAs.
MA566207 - JP 2018138019-A/138133: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: MOK_HUMAN, NM_014226, NP_055041, Q92790, Q93067, Q9UQ07, RAGE, RAGE1, uc001ylm.3
UCSC ID: uc001ylm.4
RefSeq Accession: NM_014226
Protein: Q9UQ07 (aka MOK_HUMAN)
CCDS: CCDS9971.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014226.2
exon count: 12CDS single in 3' UTR: no RNA size: 1978
ORF size: 1260CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2014.00frame shift in genome: no % Coverage: 99.09
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.