Human Gene ZNF286B (uc010vyd.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 286B (ZNF286B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:18,561,742-18,585,572 Size: 23,831 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr17:18,565,250-18,584,964 Size: 19,715 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:18,561,742-18,585,572)mRNA (may differ from genome)Protein (522 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Putative zinc finger protein 286B;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 10 C2H2-type zinc fingers.
CAUTION: Could be the product of a pseudogene.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.67 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 20.73 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -97.70251-0.389 Picture PostScript Text
3' UTR -1052.843508-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on P0CG31
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  DQ588812 - Homo sapiens piRNA piR-55924, complete sequence.
JD198627 - Sequence 179651 from Patent EP1572962.
JD272165 - Sequence 253189 from Patent EP1572962.
JD550395 - Sequence 531419 from Patent EP1572962.
JD428418 - Sequence 409442 from Patent EP1572962.
JD562203 - Sequence 543227 from Patent EP1572962.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD280278 - Sequence 261302 from Patent EP1572962.
MG753997 - Homo sapiens forkhead box O3B (FOXO3B) mRNA, complete cds.
JD462600 - Sequence 443624 from Patent EP1572962.
JD102917 - Sequence 83941 from Patent EP1572962.
JD373298 - Sequence 354322 from Patent EP1572962.
JD403725 - Sequence 384749 from Patent EP1572962.
JD503615 - Sequence 484639 from Patent EP1572962.
JD396418 - Sequence 377442 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001145045, NP_001138517, P0CG31, Z286B_HUMAN, ZNF286C, ZNF286L
UCSC ID: uc010vyd.1
RefSeq Accession: NM_001145045
Protein: P0CG31 (aka Z286B_HUMAN)
CCDS: CCDS58523.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001145045.1
exon count: 5CDS single in 3' UTR: no RNA size: 5328
ORF size: 1569CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3202.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.